Summary
Rats injected intraperitoneally with gold thioglucose (GTG, 0.3mg/g) revealed hemorrhagic lesions in the gastric mucosa 24h after the injection. However, no morphological changes were found in the central nervous system after the injection. The volume of gastric secretion and acid output increased significantly 24h after the injection (P<0.01), and gastric emptying was markedly inhibited 24h post administraion (P<0.01). There were no changes in either blood flow or hexosamine contents in the gastric mucosa. These results indicated that gastric hemorrhagic lesion was associated with increases in gastric secretion and acid output. No significant changes were found in gastrin contents in either plasma or the gastric mucosa. A subdiaphragmatic vagotomy prior to the GTG injection prevented bleeding in the gastric mucosa and lowered the gastric secretion and acid output. This indicated that the mechanism of action of GTG in producing the gastric lesion might be mediated by the vagus nerve.
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Deter RL, Liebelt RA: The development of acute gastric ulcers in rats treated with Goldthioglucose. Gastroenterology 1962;43:575–583
Takagi K, Kasuya K, Watanabe K: Studies on the drugs for peptic ulcer. A reliable method for producing stress ulcer in rats. Chem Pharm Bull 1964;12:465–472
Kurebayashi Y, Asano M, Hashizume T, et al: Changes in duodenal mucosal blood flow and mucous glycoprotein content during cysteamine-induced duodenal ulceration in rats. Arch Int Pharmacodyn Ther 1985;276:152–162
Masamune H, Yoshizawa Z: Biochemical studies on carbohydrates. Tohoku J Exp Med 1957;65:169–172
Brodie DA: A comparison of anticholinergic drugs on gastric secretion, gastric emptying, and pupil diameter in the rats. Gastroenterology 1966;50:45–50
Kasanuki J, Makino H, Matsushima Y, et al: Effect of hypophysectomy and growth hormone administration on somatostatin and gastrin content in the stomach of rats. Endocrinol Jpn 1981;28:257–260
Mayer J, Marshall LB: Specificity of gold thioglucose for ventromedial hypothalamic lesions and hyperphagia. Nature 1956;178:1399–1400
Isizaki F: Goldthioglucose-induced lesions and quantitative changes of monoamines in the rat brain. Yonago Acta Med 1974;18:1–8
Inoue S, Bray GA: The effects of subdiaphragmatic vagotomy in rats with ventromedial hypothalamic obesity. Endocrinology 1977;100:108–114
Dragstedt LR: A concept of the etiology of gastric and duodenal ulcer. Am J Roentgen 1956;75:219–229
Rhodes J, Barmardo DE, Phillips SF: Increased reflux of bile into the stomach in patients with gastric ulcer. Gastroenterology 1969;57:241–252
Harasawa S, Tani N, Suzuki S, et al: Gastric emptying in normal subjects and patients with pepetic ulcer. Gastroenterol Jpn 1974;14:1–10
Mizuno, S: Study on gastric function by means of test meal method. Gastroenterol Jpn 1966;66:847–863
George JD: New clinical method for measuring the rate of gastric emptying; the double sampling test meal. Gut 1968;9:237–242
Szabo S, Reynolds ES, Lichtenberger LM, et al: Pathogenesis of experimental duodenal ulcer; gastric hyperacidity caused by propionitrile and cysteamine in rats. Res Commun Chem Pathol Pharmacol 1977;16:311–323
Lichtenberger LM, Szabo S, Trier JS: Stimiulation of serum gastrin levels and gastric acid secretion in rat by duodenal ulcerogenic agents. Fed Proc 1976;35:217
Lichtenberger Lm, Szabo S, Reynolds ES: Gastric emptying in the rats is inhibited by the duodenal ulcerogens, cysteamine and propionitrile. Gastroenterology 1977;73: 1072–1076
Jacobson ED, Linford RH, Grossman MI: Gastric secretion in relation to mucosal blood flow studied by a celarance technic. J Clin Invest 1966;45:1–8
Harper AA, Reed JD, Smy JR: Gastric blood flow in anesthetized cats. J Physiol 1986;194:795–807
Main IHM, Whittle BJR: Gastric mucosal blood flow during pentagastrin and histamine-stimulated acid secretion in the rat. Br J Pharmacol 1973;49:534–542
Folkow B, Rubinstein EH: Behavioural and autonomic patterns evoked by stimulation of the lateral hypothalamic area in the cat. Acta Physiol Scand 1965;65:292–299
Lisander B: The hypothalamus and vagally mediated gastric relaxation. Acta Physiol Scand 1975;93:1–9
Osumi Y, Aibara S, Sakae K, et al: Central noradrenergic inhibition of gastric mucosal blood flow and acid secretion in rats. Life Science 1977;20:1407–1416
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Watanabe, H. Pathogenesis of gastric mucosal damage induced by intraperitoneal administration of gold thioglucose in rats. Gastroenterol Jpn 24, 357–364 (1989). https://doi.org/10.1007/BF02774340
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DOI: https://doi.org/10.1007/BF02774340