Summary
A 30-year-old Japanese male, who had no remarkable family history, visited our hospital with a complaint of abdominal pain, and unconjugated hyperbilirubinemia and hyperamylasemia were observed. He showed negative hemolysis tests, positive nicotinic acid test, low hepatic bilirubin UDP-glucuronyltransferase activity, decreased bilirubin diglucuronide and increased bilirubin mono-glucuronide in bile, and a decrease in serum bilirubin after phenobarbital administration. He also showed high serum amylase level, low urine amylase level, and low amylase-creatinine clearance ratio. Gel filtration of serum with Sephadex G-200 revealed the existance of macroamylase. Countercurrent immunoelectrophoresis proved binding of serum amylase to lambda type IgA. From these results, the case was diagnosed as Gilbert’s syndrome combined with macroamylasemia.
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Inoue, H., Adachi, Y., Yamashita, M. et al. A case of Gilbert’s syndrome combined with macroamylasemia. Gastroenterol Jpn 24, 320–324 (1989). https://doi.org/10.1007/BF02774331
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DOI: https://doi.org/10.1007/BF02774331