Summary
Controlled trial of D-penicillamine was carried out with low dosis in 10 patients with chronic persistent hepatitis, 11 patients with chronic aggressive hepatitis and 7 patients with liver cirrhosis. After 6 weeks and 6 months treatment mean values of transaminases improved in patients with chronic persistent hepatitis. The mean serum transaminases levels of the patients with chronic aggressive hepatitis were statistically decreased after 6 weeks treatment but not significantly lower after 6 months treatment than on entry. D-penicillamine is not effective for the treatment of patients with liver cirrhosis. Eight of 36 patients treated were withdrawn from the trial because of adverse drug toxicity side effects.
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Nakano, H., Ohnishi, S., Sugiyama, T. et al. Controlled trial of D-penicillamine with low dosis in the treatment of chronic liver diseases. Gastroenterol Jpn 15, 374–378 (1980). https://doi.org/10.1007/BF02774310
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DOI: https://doi.org/10.1007/BF02774310