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Role of plasma histamine in liver injury clinical and experimental investigations

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Plasma histamine level (PHL) was evaluated by a modified fluorometric assay (Suzuki) in the patients with various forms of liver disease as well as rabbits with liver injury. And the data obtained were compared with liver function tests in assessing the stage and prognosis of hepatic dysfunction.

In acute hepatitis, if its prognosis was “good”, as was also shown in the animal group with single dose administration of CC14, the level of plasma histamine attained a peak before that of serum transaminases, and returned to normal prior to that of the latter. In persistent and chronic hepatitis, although correlation betweenPHL and other liver function tests was poor and variable,PHL remained high. And the estimation ofPHL during the course of this state showed that it was elevated prior to that of serum transaminases, indicating high level of plasma histamine in this state, even in apparent “steady state”,’ worsening of the disease. In liver cirrhosisPHL correlated with the degree of serum transaminases as well as serum gammaglobulin. In “poor prognosis” group (patients with hepatic coma and rabbits treated with consecutive administration of CCI4)PHL increased extremely high, which was contrasted with the lowered levels of transaminases.

These results strikingly suggest that histamine is involved in liver injury and estimation of PHL in the course of hepatic disorder is useful, for a prediction of prognosis.

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Suzuki, O., Ishii, K., Nagata, H. et al. Role of plasma histamine in liver injury clinical and experimental investigations. Gastroenterol Jpn 14, 336–343 (1979).

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