Summary
Experimental colitis was induced in rabbits either by immunizing the antigens which possess the cross-reacting antigenicity with colonic mucosa, and by infusing intravenously their own lymphocytes sensitized with E. coli 014 endotoxin which may contain a high concentration of common antigen (Kunin antigen).
The hemorrhagic inflammatory changes were developed in the colon as follows; (1) three of fifteen rabbits immunized with rat colon, (2) one of three rabbits with their own E. coli, (3) six of fifteen rabbits with E. coli 014 and, (4) five of eight rabbits by infusing their own lymphocytes sensitized with E. coli 014 endotoxin.
It was suggested that the cross-reacting antigenicity with the colonic mucosa and the sensitized lymphocytes implicate in the pathogenesis of chronic ulcerative colitis.
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References
Broberger O, Perlmann P: Autoantibodies in human ulcerative colitis. J Exp Med 110: 657, 1959
Westphal O, et al: Über die Extraktion von Bakterien mit Phenol/Wasser. Z Naturforsch 7b: 148, 1952
Le Veen HH, et al: Experimental ulcerative colitis produced by anticolon sera. Annals of Surg 154: 275, 1961
Bicks RO, et al: Immunologic “colitis” in dogs. Am J Dig Dis 7: 574, 1962
Holborow EJ, et al: Autoantibody production in rabbits. VI. The production of autoantibodies against rabbit gastric, ileal and colonic mucosa. Immunology 6:551, 1963
Kunin CM: Separation, characterization, and biological significance of a common antigen in Enterobacteriacae. J Exp Med 118: 565, 1963
Perlmann P, et al: Autoantibodies to colon in rats and human ulcerative colitis: Cross reactivity with Escherichia coli O:14 antigen. PSEBM 125: 975, 1967
Lagercrantz R, et al: Immunological studies in ulcerative colitis. IV. Origin of autoantibodies. J Exp Med 128: 1339, 1968
Zweibaum A, et al: Réalisation d’une colite ulcérohémorrhagique expérimentale par immunisation bactérienne. Path Biol 16: 813, 1968
Fink S, et al: Rectal reaction to injected ulcerative colitis leucocytes and plasma. Gut 8: 20, 1967
Fink S, et al: Cell-mediated immune reaction to colon altered by bacteria. Gut 9: 629, 1968
Bendixen G: Cellular hypersensitivity to components of intestinal mucosa in ulcerative colitis and Crohn’s disease. Gut 10: 631, 1969
Shorter RG, et al: Further studies of in vitro cytotoxicity of lymphocytes for colonic epithelial cells. Gastroenterology 57: 30, 1969
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Kuroe, K., Kitagawa, K., Chiba, M. et al. Experimental colitis in rabbits. Gastroenterol Jpn 13, 33–42 (1978). https://doi.org/10.1007/BF02774152
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DOI: https://doi.org/10.1007/BF02774152