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Studies on the CEA-like substance in gastric juice

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Summary

Concentration and heterogeneity of CEA-like substance in gastric juice were studied using radioimmunoassay. Statistically significant increase of CEA-like substance in gastric juice was found in advanced atrophic gastritis (P<0.01), early gastric cancer (P<0.05) and advanced gastric cancer (P<0.01) as compared with normal subjects.

In cases with atrophic gastritis with a high degree of intestinal metaplasia, the concentrations above 300µg/dl were noticed. The results indicate that increased concentrations of CEA-like substance in gastric secretions may strongly suggest the presence of a marked intestinal metaplasia and/or cancerous changes of gastric mucosae, including the early cancer.

The distribution of CEA activity in gel filtration fractions of gastric juice was compared using kits of two different radioimmunoassay systems. The patterns of CEA activities were different between the two different kits used, but the main peaks were located in the fractions with the molecular weight of 20X104 daltons corresponding to that of serum CEA. It is considered, however, that the CEA-like substance in gastric juice specimens may be more or less heterogenous when any of the methods is used.

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Authors and Affiliations

  1. Department of Internal Medicine (Section I), Sapporo Medical College, S. 1, W. 16, Chuō-ku, 060, Sapporo, Japan

    Makoto Kawaharada M.D., Shozō Fukuya M.D., Takashi Suzuki M.D., Minoru Sudo M.D., Yoshikazu Akahonai M.D., Akira Yachi M.D. & Takeo Wada M.D. (Professor)

Authors
  1. Makoto Kawaharada M.D.
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  2. Shozō Fukuya M.D.
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  3. Takashi Suzuki M.D.
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  4. Minoru Sudo M.D.
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  5. Yoshikazu Akahonai M.D.
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  6. Akira Yachi M.D.
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  7. Takeo Wada M.D.
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Kawaharada, M., Fukuya, S., Suzuki, T. et al. Studies on the CEA-like substance in gastric juice. Gastroenterol Jpn 13, 8–12 (1978). https://doi.org/10.1007/BF02774148

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  • DOI: https://doi.org/10.1007/BF02774148

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