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Leukocyte migration inhibition induced by the combination of drug and a liver constituent in patients with drug-induced hepatitis

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Summary

The leukocyte migration inhibition test in agarose medium was performed in 23 cases of clinically diagnosed drug-induced hepatitis. When the test antigen was the combination of soluble phase of a liver homogenate fractionated by Sephadex G-100 which should have contained liver specific antigen and the offending drug the leukocyte migration was inhibited in 86% of cases. Whereas none of 12 cases of drug allergy without hepatic injury showed a positive result with the same combination of antigens. Other organ homogenate-muscle and kidney-never gave positive results when mixed with the offending drugs in cases of drug-induced hepatitis.

It was concluded that in hypersensitivity type drug-induced hepatitis cell-mediated immunity might be established to the complex of liver specific antigen and the drug.

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Authors and Affiliations

  1. Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomochi, 160, Shinjuku-ku, Tokyo, Japan

    Toshio Morizane

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  1. Toshio Morizane
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Grateful acknowledgement is made to Prof. Tsuchiya and Associate Prof. Kamegaya for constant interest and guidance in this study.

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Morizane, T. Leukocyte migration inhibition induced by the combination of drug and a liver constituent in patients with drug-induced hepatitis. Gastroenterol Jpn 13, 281–289 (1978). https://doi.org/10.1007/BF02774051

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  • DOI: https://doi.org/10.1007/BF02774051

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