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A case report of primary hepatic carcinoma with prolonged HV virus infection and monoclonal gammopathy

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Summary

A case of alpha-feto protein (AFP) positive hepatic cell carcinoma has been presented in which the appearance of a mono-clonal gammopathy can be explained by persistent infection with HB virus (HBV). The patient, a fifty year old male, developed acute jaundice with hepatitis in July, 1952, and died of an hepatic cell carcinoma in December, 1973. The interest of this case lies in the fact that during the seven months prior to be patient’s demise, a mono-clonal gammopathy of IgG (L type), together with positive titeres for HBs Ag (adr) and AFP, was demonstrated.

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References

  1. Okabayashi, A.: Prolonged sensitization. An immunopathological study of infection. Tr. Soc. Path. Jap., 51: 223–242, 1962 (in Japanese).

    Google Scholar 

  2. Fudenberg, H.H.: Immunologic deficiency, autoimmune diseases, and lymphoma; Observations, implications, and speculations. Arthritis Rheum., 9: 464–472, 1966.

    Article  PubMed  CAS  Google Scholar 

  3. Tsuji, T., Ohta, Y., Kobayashi, T., Danjo, H., Oka, K., Mizuno, Y., Sato, M., Izawa, T., Miki, H., Kosaka, K., Imai, M., Miyamoto, C. and Hirohata, M.: Heavy-chain (Fc fragment) disease. Report of the first case in Japan. J. Jap. Soc. Int. Med., 58: 1202–1209, 1969 (in Japanese).

    CAS  Google Scholar 

  4. Tsuji, T.: Heavy-chain (Fc fragment) disease— Immunological reactions of the first case in Japan and the incorporation of14C-amino acids into the protein in vitro—. Acta Haem. Jap., 33: 89–99, 1970.

    CAS  Google Scholar 

  5. Imai, M., Yamashita, Y., Miyakawa, Y. and Mayumi, M.: Haemagglutination inhibition assay of the common determinants and subspecificities of Australia antigen. Immunol., 27: 871–878, 1974.

    CAS  Google Scholar 

  6. Pesendorfer, F., Krassnitzky, O. und Wewalka, F.: Immunoelectrophoretisher Nachweis von “hepatitisassociated-antigen” (Au/SH antigen). Klin. Wschr., 48: 58–59, 1970.

    Article  PubMed  CAS  Google Scholar 

  7. Vyas, G. and Schulman, N.R.: Hemagglutination assay for antigen and antibody associated with viral hepatitis. Science, 170: 332–333, 1970.

    Article  PubMed  CAS  Google Scholar 

  8. Tsuji, T., Tokuyama, K., Okada, T., Takata, S., Naito, K., Kosaka, K., Takahashi, T. and Mayumi, M.: Detection of liver HBc antigen and its antibody in sera from viral hepatitis by the immunofluorescent complement technique. Acta Med. Okayama, 30: 61–67, 1976.

    PubMed  CAS  Google Scholar 

  9. Gold, P. and Freedman, S.O.: Specific carcinoembryonic antigens of the human digestive system. J. Exp. Med., 122: 467–481, 1965.

    Article  PubMed  CAS  Google Scholar 

  10. Abelev, G.I.: Production of embryonal serum αglobulin by hepatomas. Review of experimental and clinical data. Cancer Res., 28: 1344–1350, 1968.

    CAS  Google Scholar 

  11. Osserman, E.F., Llockers, M., Halper, J. and Fischel, R.E.: Effects of lysozyme on normal and transformed mammalian cells. Nature, 243: 331–335, 1973.

    Article  PubMed  CAS  Google Scholar 

  12. Edmondson, H.A. and Steiner, P.E.: Primary carcinoma of liver: study of 100 cases among 48,900 necropsies. Cancer, 7: 462–503, 1954.

    Article  PubMed  CAS  Google Scholar 

  13. Mellors, R.C. and Korngold, L.: The cellular origin of human immunoglobulins. J. Exp. Med., 118: 387–395, 1963.

    Article  PubMed  CAS  Google Scholar 

  14. Tsuji, T., Ogawa, K. and Kosaka, K.: An immunofluorescent study of circulating anti-liver antibodies in chronic liver diseases. Acta Pathol. Jap., 15: 273–286, 1965.

    CAS  Google Scholar 

  15. Tsuji, T., Naito, K., Tokuyama, K., Okada, T. and Kosaka, K.: Detection of HBs antigen in routine paraffin embedded liver tissue by enzyme-labelled antibody technique. Acta Med. Okayama, 30: 69–73, 1976.

    PubMed  CAS  Google Scholar 

  16. Nakane, P. and Kawaoi, A.: Peroxidase labeled antibody. A new method of conjugation. J. Histochem. Cytochem., 22: 1084–1091, 1974.

    PubMed  CAS  Google Scholar 

  17. Tsuji, T., Nozaki, H. and Naito, K.: In Kuroyanagi, T., Otaka, Y. and Matsuhashi, T. (Eds.), Liver Disorders with Immunological Aspect. The liver and complements, pp. 183–211, Igaku Shoin Ltd., Tokyo, 1973 (in Japanese).

    Google Scholar 

  18. Zawadzki Z.A. and Edwards, G.A.: Dysimmunoglobulinemia associated with hepatobiliary disorders. Amer. J. Med., 40: 196–202, 1970.

    Article  Google Scholar 

  19. Blumberg, B.S., Alter, H.J. and Visnich, S.A.: A ‘new’ antigen in leukemic sera. J. Amer. Med. Ass., 191: 541–546, 1965.

    CAS  Google Scholar 

  20. Dane, D.S., Cameron, C.H. and Briggs, M.: Viruslike particles in serum of patients with Australiaantigen-associated hepatitis. Lancet, i: 695–698, 1970.

    Article  Google Scholar 

  21. Simons, M.J., Yap, E.H., Yu, M., Seach, C.S., Chew, B.K., Fung, W.P., Tan, A.Y.O. and Shanmugaratnam, K.: Frequency of Australia antigen in Chinese patients in Singapore with hepatocellular carcinoma. Am. J. Dis. Child, 123: 358–359, 1972.

    PubMed  CAS  Google Scholar 

  22. Engelhardt, N.V., Goussev, A.I., Shipova, L.J. and Abelev, G.I.: Immunofluorescent study of α-fetoprotein (αFP) in liver and liver tumors. 1. Technique of αFP localization in tissue sections. Int. J. Cancer, 7: 198–206, 1971.

    Article  PubMed  CAS  Google Scholar 

  23. Fleming, A.: On a remarkable bacteriolytic element found in tissues and secretions. Proc. Roy. Soc, B 93: 306–317, 1922.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. The First Department of Internal Medicine, Okayama University Medical School, 5-1, 2-chome, Shikata-cho, 700, Okayama, Japan

    Takao Tsuji M.D., Katsuyuki Tokuyama M.D., Kunihiko Naito M.D., Satoru Okazaki M.D., Toru Shinohara M D., Kiyonori Araki M.D., Takeshi Okada M.D., Hajime Nozaki M.D. & Hideo Nagashima M.D.

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  1. Takao Tsuji M.D.
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  2. Katsuyuki Tokuyama M.D.
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  3. Kunihiko Naito M.D.
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  4. Satoru Okazaki M.D.
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  5. Toru Shinohara M D.
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  6. Kiyonori Araki M.D.
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  7. Takeshi Okada M.D.
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  8. Hajime Nozaki M.D.
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  9. Hideo Nagashima M.D.
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Tsuji, T., Tokuyama, K., Naito, K. et al. A case report of primary hepatic carcinoma with prolonged HV virus infection and monoclonal gammopathy. Gastroenterol Jpn 12, 69–75 (1977). https://doi.org/10.1007/BF02774005

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  • DOI: https://doi.org/10.1007/BF02774005

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