Summary
In order to clarify the pathophysiology of digestive disorders which are caused with anticancer agents, Mitomycin C was intravenously administrated to rats and the ultrastructure of the pancreas was studied.
The alteration of acinar cells after under 4 daily administrations of 1.0 mg/Kg of Mitomycin C was not remarkable and in an early stage returned to normal structure. In above 8 daily administrations of 1.0 mg/Kg of Mitomycin C, however, pronounced degeneration of acinar cells was induced and acinar cells did not recover to the previous level, but die within one month. The ultrastructufal changes induced by Mitomycin C were mainly aggregation of chromatin in the nuclei, tubularly dilatation of the rough endoplasmic reticulum, and swelling of the mitochondria.
It was surmised that the biosynthesis and supply of protein such as digestive enzymes were not amply carried on; hence, the chemotherapy could give rise to severe digestion disorders. It appeared necessary to further study the dosage and dosage schedule of the anticancer agents, along with the necessity for taking ample care of patients presenting such disorders.
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References
Fukunaga, H.: Clinical significance of Mitomycin C as an adjuvant chemotherapeutic agent for postoperative stomach cancer. A long-term follow-up study on 249 patients. J. Osaka Med. College, 34: 60–74, 1975. (Jap.)
Ichioka, G.: A study on the preoperative a) oministration of anticancer drug (Mitomycin C : against gastric cancer. Arch. Jap. Chir., 43(2) 124–145, 1974. (Jap.)
3) Shiba, S. and Taguchi, T.: Mitomycin—Its experimental research and clinical application— p 1, Igaku Shoin, Tokyo. (Jap.)
4) Matsunaga, F. and Kubo, A. : Practice of cancer chemotherapy, p 47, Nankodo, Kyoto, 1971. (Jap.)
Teranishi, S. et al.: Effects of anticancer agents of the intestinal epithelium. A morphologic study. Gastroenterologia Japonica, 11(3): 182–188, 1976.
Teranishi, S.: A study on effects of anticancer agents of the intestinal epithelium. Jap. J. Surg. Soci., 77(9): 1244–1245, 1976. (Jap.)
Terahata, Y. and Takahashi, A.: Effect of Mitomycin C on the liver cells —with special reference to the electron microscopic observations—., J. Ther., 47: 1136–1140, 1965. (Jap.)
Ushijima, H.: Effect of Mitomycin C on the liver with special reference to the changes in fine structure of rabbit liver cells. Krume Med. J., 17: 1–31, 1973.
Ichikawa, A.: Fine structural changes in response to hormonal stimulation of the perfused canine pancreas. J. Cell Biol., 24: 369–385, 1965.
Ekholm, R. & Edlund, Y.: Ultrastructure of the human exocrine pancreas. J. Ultrastruc. Res., 2: 453–481, 1959.
Ekholm, R. et al.: The ultrastructural organization of the rat exocrine pancreas. 1. Acinar cells., 11. Centroacinar cells, intercalary and intralobular ducts. J. Ultrastruc. Res., 7: 61–101, 1962.
Palade, G.: Intracellular aspects of the process of protein synthesis. Science, 189: 347–358, 1975.
Jamieson, J.D.: Membranes and secretion, in “Cell Membranes: Biochemistry, Cell biology & Pathology” eds. Weissmann, G. & Claiborne, R., pp. 143–152, H.P. Publishing, New York, 1975.
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Teranishi, S., Kitade, F. & Itaya, H. Ultrastructural investigation of the effect of mitomycin c on the rat exocrine pancreas. Gastroenterol Jpn 12, 28–35 (1977). https://doi.org/10.1007/BF02773999
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DOI: https://doi.org/10.1007/BF02773999