Summary
The effect of omeprazole on gastric acid output was studied in rats before and during stimulation by continuous administration of tetragastrin at 50 Μg/kghour. From 5 to 20 mg/kg of omeprazole was given to animals intraperitoneally, perorally and intravenously from 2 to 24 hours before the gastric secretory study was started, and the respective effects on acid secretion were compared. In each administration group, 20 mg/kg of omeprazole was the most potent among the groups receiving 5, 10 or 20 mg/kg, when the drug was given 2 hours before the study. There were statistically significant differences between the control group given tetragastrin only and each of the groups given 20 mg/kg of omeprazole perorally, intraperitoneally and intravenously. There was no significant difference among the groups given 20 mg/kg of omeprazole intraperitoneally, intravenously and perorally. The effect of 20 mg/kg of omeprazole continued at least 24 hours after the agent was administered perorally.
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Segawa, K., Nakazawa, S., Tsukamoto, Y. et al. Effect of omeprazole on gastric acid secretion in rat: Evaluation of dose, duration of effect, and route of administration. Gastroenterol Jpn 22, 413–418 (1987). https://doi.org/10.1007/BF02773807
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DOI: https://doi.org/10.1007/BF02773807