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Cronkhite-Canada syndrome

A case report and analytical review of 23 other cases reported in Japan

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Summary

A case study is presented of a 57-year-old male who showed typical clinical features of Cronkhite-Canada syndrome. Numerous polypoid lesions were found in the stomach, duodenum, ileum, colon and rectum accompanied with characteristic ectodermal changes. Tests indicated a protein-losing gastroenteropathy. Intestinal lactase deficiency was demonstrated by the lactose tolerance test. Scanning electronmicroscopy of the gastric and colonic mucosa revealed prominent secretion of mucoid substances and distortion in the gastric pits and colonic crypts. These abnormal findings were interpreted as having a direct relationship to the loss of protein into the gastrointestinal tract.

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Authors and Affiliations

  1. The Third Department of Internal Medicine, Ehime University School of Medicine, Matsuyama, Japan

    Yasuyuki Ohta M.D.

  2. Department of Radiology, Ehime University School of Medicine, Matsuyama, Japan

    Nobuyoshi Ishikawa M.D.

  3. The Third Department of Internal Medicine, Ehime University School of Medicine, Shizukawa Shigenobu-cho Onsen-gun, 791-02, Ehime Prefecture, Japan

    Kunijiro Suzuki M.D.

Authors
  1. Kunijiro Suzuki M.D.
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  2. Masayoshi Uraoka M.D.
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  3. Takashi Funatsu M.D.
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  4. Hiroshi Sakaue M.D.
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  5. Morikazu Onji M.D.
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  6. Yasuyuki Ohta M.D.
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  7. Nobuyoshi Ishikawa M.D.
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Suzuki, K., Uraoka, M., Funatsu, T. et al. Cronkhite-Canada syndrome. Gastroenterol Jpn 14, 441–449 (1979). https://doi.org/10.1007/BF02773732

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  • DOI: https://doi.org/10.1007/BF02773732

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