Gastroenterologia Japonica

, Volume 15, Issue 1, pp 41–48 | Cite as

The effects of intravenously administered chlorophyll-a on naturally occurring serum protease inhibitors in rabbits

  • Akira Yoshida
  • Osamu Yokono
  • Toshitsugu Oda
Original Article


Effects of intravenously administered protease inhibitors on naturally occurring serum inhibitors were investigated in rabbits. Water-dispersed chlorophyll-a, trasylol and leupeptin were tested as exogenous protease inhibitors in the experiments. From the results of experiments, it was concluded that:
  1. 1)

    Pretreatment with chlorophyll-a infusion into rabbits, most effectively prevented the rapid consumption of naturally occurring serum protease inhibitors after successive trypsin infusion, and the duration of its action was observed longest when compared with other exogenous inhibitors, such as trasylol or leupeptin.

  2. 2)

    Final therapeutic effects of these exogenous protease inhibitors seem to have depended upon the disappearing way of the administered inhibitors from the blood in certain period of time, as well as upon biochemical potency of their inhibiting activity.


Key Words

pancreatitis chlorophyll-a protease inhibitors 


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Copyright information

© The Japanese Society of Gastroenterology 1980

Authors and Affiliations

  • Akira Yoshida
    • 1
  • Osamu Yokono
    • 2
  • Toshitsugu Oda
    • 1
  1. 1.The First Department of Medicine, Faculty of MedicineUniversity of TokyoTokyoJapan
  2. 2.Health Administration CenterTokyo University of Foreign StudiesJapan

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