Skip to main content
SpringerLink
Log in

Studies on circulating immune complexes of the liver disease. 4. Clq binding activity

  • Original Article
  • Published:
Gastroenterologia Japonica Aims and scope Submit manuscript

Summary

Serum Clq binding activity (ClqBA) is increased in diabetes mellitus with liver injury, carcinoma of gastrointestinal tract with metastatic liver and chronic liver disease (CLD). Significant elevations of ClqBA level are observed in the order of liver cirrhosis, chronic aggressive hepatitis and chronic persistent hepatitis. In CLD there are significant correlations between ClqBA and γ-globulin, rheumatoid factor, anti-DNA-antibody, CH50, C3, C4, C3-activator and HBsAg.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Agneilo V, Winchester RJ, Kunkel HG: Precipitin reactions of the Clq component of complement with aggregated γ-globulin and immune complexes in gel diffusion. Immunol 19: 909–919, 1970

    Google Scholar 

  2. Winchester RJ, Kunkel HG, Agneilo V: Occurrence of γ-globulin complexes in serum and joint fluid of rheumajor arthritis patients: use of monoclonal rheumatoid doctors as reagents for their demonstration. J Exp Med 134: 286s-295s, 1971

    PubMed  CAS  Google Scholar 

  3. Nydegger UE, Lamert PH, Gerber H, Miescher PA: Circulating immune complexes in the serum in systemic lupus erythematosus and carriers of hepatitis B antigen quantitation by binding to radiolabeled Clq. J Clin Invest 54: 297–309, 1974

    PubMed  CAS  Google Scholar 

  4. Theofilopoulos AN, Wilson CB, Bokisch VA, Dixon FJ: Binding of soluble immune complexes to human lymphoblastoid cells. II. use of Raji cells to detect circulating immune complexes in animal and human sera. J Exp Med 140: 1230–1244, 1974

    Article  PubMed  CAS  Google Scholar 

  5. Onyewotu II, Holborow EJ, Johnson GD: Detection and radioassay of soluble circulating immune complexes using guinea pig peritoneal exudate cells. Nature 248: 156–159, 1974

    Article  PubMed  CAS  Google Scholar 

  6. Cowdery JS Jr, Treadwell PE, Fritz RB: A radioimmunoassay for human antigen-antibody complexes in clinical material. J Immunol 114: 5–9, 1975

    PubMed  CAS  Google Scholar 

  7. Sobel AT, Bokisch VA, Muller-Eberhard HJ: Clq deviation test for the detection of immune complexes, aggregates of IgG, and bacterial products in human serum. J Exp Med 142: 139–150, 1975

    Article  PubMed  CAS  Google Scholar 

  8. Luhrhuma AZ, Cambiano CL, Masson PL, Heremans JF: Detection of circulating antigen-antibody complexes by their inhibitory effect on the agglutination of IgG-coated particles by rheumatoid factor of Clq. Clin Exp Immunol 25: 212–226, 1976

    Google Scholar 

  9. Gabriel A, Agneilo V: Detection of immune complexes: the use of radioimmunoassays with Clq and monoclonal rheumatoid factor. J Clin Invest 59: 990–1001, 1977

    PubMed  CAS  Google Scholar 

  10. Fletcher DS, Tsau-Yen Lin: Quantitation of immune complexes by competitive inhibition of binding of Clq to insoluble IgG aggregates. J Immunol Methods 15:

  11. Svehag SE: A solid-phase radioimmunoassay for Clqbinding immune complexes: 1.δ IgG as indicator molecule. Scand J Immunol 4: 687–697, 1975

    Article  PubMed  CAS  Google Scholar 

  12. Luthra HS, McDuffie FC, Hunder GG, Samayoa EA: Immune complexes in sera and synovial fluids of patients with rheumatoid arthritis: radioimmunoassay with monoclonal rheumatoid factor. J Clin Invest 56: 458–466, 1975

    Article  PubMed  CAS  Google Scholar 

  13. Farrell H, Sogaard H, Svehag SE: Detection of IgG aggregates or immune complexes using solid-phase Clq and protein A-rich Staphylococcus aureus as an indicator system. Scand J Immunol 4: 673–680, 1975

    Article  PubMed  CAS  Google Scholar 

  14. Hay FC, Nineman LJ, Roitt IM: Routine assay for the detection of immune complexes of known immunoglobulin class using solid-phase Clq. Clin Exp Immunol 24: 396–400, 1976

    PubMed  CAS  Google Scholar 

  15. Ahlstedt S, Hanson LA, Wadsworth C: A Clq immunosorbent assay compared with thin-layer gel nitration for measuring IgG aggregates. Scand J Immunol 5: 293–298, 1976

    Article  PubMed  CAS  Google Scholar 

  16. Agnello V, Koffler D, Eisenberg JW, Winchester RJ, Kunkel HG: Clq precipitates in the sera of patients with systemic lupus erythematosus and other hypocompletemic states: characterization of high and low molecula weight types. J Exp Med 134: 228s-241s, 1971

    PubMed  CAS  Google Scholar 

  17. Lieberman P, Rice MC, Mallette JE Jr: Studies of urticaria and acute serum sickness with Clq precipitin test. Arch Intern Med 137: 440–442, 1977

    Article  PubMed  CAS  Google Scholar 

  18. Zubler RH, Nydegger U, Perrin LH, Fehr K, McCormic J, Lambert PH, Miescher PA: Circulating and intra-articular immune complexes in patients with rheumatoid arthritis: correlation of125I-Clq binding activity with monoclonal and biological features of the disease. JDlin Invest 57: 1308–1319, 1976

    CAS  Google Scholar 

  19. Nydegger UE, Zubler RH, Gabay R: Circulating complement breakdown products in patients with rheumatoid arthritis: correlation between plasma C3d, circulating immune complexes, and clinical activity. J Clin Invest 59: 862–868, 1977

    PubMed  CAS  Google Scholar 

  20. Rossen RD, Reisberg MA, Hersh EM, Gutterman JU: The Clq binding test for soluble immune complexes: clinical correlations obtained in patients with cancer. J Natl Cancer Inst 58: 1205–1215, 1977

    PubMed  CAS  Google Scholar 

  21. Teshima H, Wanebo H, Pinsky C, Noorbibi K: Circulating immune complexes detected by125I-Clq deviation test in sera of cancer patients. J Clin Invest 59:1134–1142, 1977

    PubMed  CAS  Google Scholar 

  22. Moak JL, Kageller WV, Cimo PL, Blakely RW, Rossen RD, Haesse W: Intravascular hemolysis, thrombocytopenia, leukopenia, and circulating immune complexes after jejunal-ileal bypass surgery. Ann Intern Med 86: 576–578, 1977

    Google Scholar 

  23. Lurhiima AZ, Ricconi H, Masson PL: The occurrence of circulating immune complexes and viral antigens in idiopathic thrombocytopenic purpura. Clin Exp Immunol 28: 49–55, 1977

    Google Scholar 

  24. Tappeiner G, Heine KG, Kahl JC, Jordon RE: Clq binding substances in pemphigus and bullous pemphigoid: detection with a125I-Clq binding assay. Clin Exp Immunol 28: 40–48, 1977

    PubMed  CAS  Google Scholar 

  25. Tung KSK, Kim B, Bjorvatn B, Kronvall G, McLaren LC, Williams RC Jr: Discrepancy between Clq deviation and Raji cell tests in detection of circulating immune complexes in patients with leprosy. J Infec Dis 136:216–221, 1977

    CAS  Google Scholar 

  26. Wands JR, Dienstag JL, Bhan AK, Feller ER, Isselbacher KJ: Circulating immune complexes and complement activation in primary biliary cirrhosis. N Engl J Med 298: 233–237, 1978

    Article  PubMed  CAS  Google Scholar 

  27. Thomas HC, De Villiers D, Potter B, Hodgson H, Jain S, Jewell DP, Sherlock S: Immune complexes in acute and chronic liver disease. Clin Exp Immunol 31: 150–157, 1978

    PubMed  CAS  Google Scholar 

  28. Yonemasu K, Stroud RM: Clq: rapid purification method for preparation of monospecific antisera and for biochemical studies. J Immunol 106: 304–313, 1971

    PubMed  CAS  Google Scholar 

  29. Heusser C, Boesman M, Nordin JH: Effect of chemical and enzymatic radioiodination on in vitro human Clq activities. J Immunol 110: 820–828, 1973

    PubMed  CAS  Google Scholar 

  30. Arima T, Narumato J, Shimomura H, Suwaki K, Kunishi K, Yasuhara T, Nagashima H: Studies on circulating immune complexes of the liver disease. 3. conditions for Clq binding assay and low molecular weight Clq reactants. Gastroent Jpn 15: 20–26, 1980

    CAS  Google Scholar 

  31. Mancini G, Carbonara AO, Hermans JF: Immunochemical quajititation of antigens by single radial immunodiffusion. Immunochemistry 2: 235–254, 1965

    Article  PubMed  CAS  Google Scholar 

  32. Kosmidis JC, Leader-Williams LK: Complement levels in acute infectious hepatitis and serum hepatitis. Clin Exp Immunol 11: 31–35, 1972

    PubMed  CAS  Google Scholar 

  33. Alpert E, Isselbacher KJ, Schur PH: The pathogenesis of arthritis associated with viral hepatitis: complement-component studies. N Engl J Med 285: 185–189, 1971

    Article  PubMed  CAS  Google Scholar 

  34. Thompson RA, Carter R, Stokes RP: Serum immunoglobulins, complement component levels and autoantibodies in liver disease. Clin Exp Immunol 14: 335–346, 1973

    PubMed  CAS  Google Scholar 

  35. Charlesworth JA, Lawrence S, Worsdall PA: Acute hepatitis: Significance of changes in complement components. N Engl J Med 28: 496–501, 1977

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The First Department of Internal Medicine, Okayama University Medical School, 2-5-1 Shikata-cho, 700, Okayama, Japan

    Terukatsu Arima M.D. & D.Sci., Jin Narumoto M.D., Hiroyuki Shimomura M.D., Kinichiro Suwaki M.D., Kensuke Kunishi M.D., Takashi Yasuhara M.D. & Hideo Nagashima M.D.

Authors
  1. Terukatsu Arima M.D. & D.Sci.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jin Narumoto M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hiroyuki Shimomura M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kinichiro Suwaki M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Kensuke Kunishi M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Takashi Yasuhara M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Hideo Nagashima M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Arima, T., Narumoto, J., Shimomura, H. et al. Studies on circulating immune complexes of the liver disease. 4. Clq binding activity. Gastroenterol Jpn 15, 27–32 (1980). https://doi.org/10.1007/BF02773701

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02773701

Key Words

Search

Navigation