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Early lesions and development of primary hepatocellular carcinoma in man—association with hepatitis B viral infection

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Summary

It is well known that primary hepatocellular carcinoma could be derived from chronic hepatitis and liver cirrhosis in epidemiologic studies. However, it is still not clear what kinds of hepatocyte are premalignant cells. Recently we have focused on liver cell dysplasia as a possible premalignant cell, and showed localization of α-fetoprotein in the cytoplasma of these cells. Although the dysplastic cells were often seen in the liver of chronic active hepatitis, hepatitis B virus associated DNA polymerase activity was also significantly high in the sera from the patients with chronic active hepatitis. In this paper, we discuss the possible role of hepatitis B virus through hepatocarcinogenesis in human.

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Authors and Affiliations

  1. The 1st Dept. of Int. Med., Yamaguchi Univ., Sch. of Med., Ube City, 755, Yamaguchi Pref., Japan

    Kiwamu Okita M.D., Takahiro Kodama M.D., Toshinori Harada M.D., Kenichi Noda M.D., Yohei Fukumoto M.D., Toshihiko Takenami M.D., Kojiro Shigeta M.D., Minoru Mizuta M.D. & Tadayoshi Takemoto M.D.

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  1. Kiwamu Okita M.D.
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  2. Takahiro Kodama M.D.
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  3. Toshinori Harada M.D.
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  4. Kenichi Noda M.D.
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  5. Yohei Fukumoto M.D.
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  6. Toshihiko Takenami M.D.
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  7. Kojiro Shigeta M.D.
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  8. Minoru Mizuta M.D.
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  9. Tadayoshi Takemoto M.D.
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Okita, K., Kodama, T., Harada, T. et al. Early lesions and development of primary hepatocellular carcinoma in man—association with hepatitis B viral infection. Gastroenterol Jpn 12, 51–57 (1977). https://doi.org/10.1007/BF02773626

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  • DOI: https://doi.org/10.1007/BF02773626

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