Summary
Physiological and morphological changes of small intestine after hyperosmolar glucose infusion into canine jejunum were studied using in vivo perfusion model.
Infusion of 40 ml of 50% and 20% glucose solution into the jejunal loops induced biphasic osmolar degression in the lumen. Osmolarity of jejunal venous blood was rapidly increased and maintained the maximal level (approximately 320 mOM/L).
Blood flow to the jejunal loop was significantly increased after 50% glucose infusion compared to 5% glucose infusion.
Most characteristic electron microscopic change of jejunal epithelial cell was pseudo-pod like process projected into the jejunal lumen, which was very similar to that of cholera.
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Fukushima, T., Ishiguro, N., Kito, F. et al. Intestinal responses to hyperosmolar glucose infusion in dogs. Gastroenterol Jpn 12, 30–38 (1977). https://doi.org/10.1007/BF02773622
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DOI: https://doi.org/10.1007/BF02773622