Skip to main content

Advertisement

SpringerLink
Log in

Clinical studies on carcinoembryonic antigen in pancreatic cancer

  • Original Article
  • Published:
Gastroenterologia Japonica Aims and scope Submit manuscript

Summary

We studied serum carcinoembryonic antigen (CEA) levels in 82 patients. Thirty-four of these had benign diseases while 48 had malignant diseases. Highest incidence and levels of CEA occurred in the sera of patients with pancreatic cancer and stomach cancer. In this paper we focused our particular attention on the serum CEA of 25 pancreatic cancer patients, and examined differences in serum CEA levels in relation to histologie differentiation and sites of pancreatic cancer. No statistical difference in serum CEA level was found among various histologic types and sites of the pancreatic cancer. Clinical courses of two patients with pancreatic cancer were also studied. Serial determinations of CEA levels are most useful in assessing the effect of operation or chemotherapies and are a useful indicator for differentiating pancreatic cancer from chronic pancreatitis but cannot be a conclusive factor for the diagnosis. Finally, we correlated serum CEA levels with those of RNase and confirmed a positive correlation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Jacobs A, et al: Ferritin in serum, clinical and biochemical implications. N Engl J Med 292: 951, 1975

    Article  PubMed  CAS  Google Scholar 

  2. Abelev GI: Alpha-fetoprotein in ontogenesis and its association with malignant tumors. Adv Cancer Res 14: 295, 1971

    Article  PubMed  CAS  Google Scholar 

  3. Gold P, et al: Demonstration of tumor specific antigens in human colonic carcinoma by immunological tolerance and absorption techniques. J Exp Med 121: 439, 1965

    Article  PubMed  CAS  Google Scholar 

  4. Gold P, et al: Specific carcinoembryonic antigens of the human digestive system. J Exp Med 122: 467, 1965

    Article  PubMed  CAS  Google Scholar 

  5. Lokich JJ, et al: Carcinoma of the pancreas. Am J Gastroenterol 62: 481, 1974

    PubMed  CAS  Google Scholar 

  6. Ona FV, et al: Carcinoembryonic antigen (CEA) in the diagnosis of pancreatic cancer. Cancer 31: 324, 1973

    Article  PubMed  CAS  Google Scholar 

  7. Delwiche R, et al: Carcinoembryonic antigen in pancreatitis. Cancer 31: 328, 1973

    Article  PubMed  CAS  Google Scholar 

  8. Martin EW, et al: Carcinoembryonic antigen. Clinical and historical aspects. Cancer 37: 62, 1976

    Article  PubMed  Google Scholar 

  9. Reddi KK, et al: Elevated serum ribonuclease in patients with pancreatic cancer. Proc Natl Acad Sci USA 73: 2308, 1976

    Article  PubMed  CAS  Google Scholar 

  10. Funakoshi A, et al: Serum ribonucleases in pancreatic cancer: Relation to tumor histology. Gastroenterol Jpn (in press)

  11. Nakayama K, et al: Investigation of serum CEA assay (RIA) by Sandwich method. Rinsho to Kenkyu 53: 3652, 1976 (Jpn)

    Google Scholar 

  12. Booth SN, et al: Serum carcinoembryonic antigen in clinical disorders. Gut 14: 794, 1973

    Article  PubMed  CAS  Google Scholar 

  13. Gerfo P, et al: Carcinoembryonic antigen and prognosis in patients with colon cancer. Ann Surg 181: 81, 1975

    Article  PubMed  Google Scholar 

  14. V Nagell JR Jr, et al: Carcinoembryonic antigen in patients with gynecologic malignancy. Cancer 35: 1372, 1975

    Article  Google Scholar 

  15. Bullen AW, et al: Diagnostic usefulness of plasma carcinoembryonic antigen levels in acute and chronic liver disease. Gastroenterology 73: 673, 1977

    PubMed  CAS  Google Scholar 

  16. Vider M, et al: Carcinoembryonic antigen (CEA) monitoring in the management of radiotherapeutic and chemotherapeutic patients. Am J Roentgenol Radium Ther Nucl Med, 124: 630 1975

    PubMed  CAS  Google Scholar 

  17. Zamcheck N, et al: Prognostic factors in colon carcinoma. Human Pathology 6: 31, 1975

    Article  PubMed  CAS  Google Scholar 

  18. Burtin P, et al: Immunological study of polyps of the colon. J Natl Cancer Inst 48: 25, 1972

    Google Scholar 

  19. Isaacson P, et al: The demonstration of carcinoembryonic antigen in colorectal carcinoma and colonic polyps using immunoperoxidase technique. Cancer 38: 1348, 1976

    Article  PubMed  CAS  Google Scholar 

  20. Goldenberg DM, et al: Carcinoembryonic antigen in histopathology: Immunoperoxidase staining of conventional tissue sections. J Natl Cancer Inst 57: 11, 1976

    PubMed  CAS  Google Scholar 

  21. Burtin P, et al: Immunohistological localization of carcinoembryonic antigen and nonspecific crossreacting antigen in gastrointestinal normal and tumoral tissues. Cancer Res 33: 3299, 1973

    PubMed  CAS  Google Scholar 

  22. Pustaszeri G, et al: Carcinoembryonic antigen (CEA) in non digestive cancerous and normal tissues. Immunochemistry 10: 197, 1973

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. 3rd Department of Internal Medicine, Faculty of Medicine, Kyushu University, 11 Maedashi 3-chome, Higashi-ku, 812, Fukuoka City, Japan

    Takashi Yamauchi M.D., Akihiro Funakoshi M.D., Hideyuki Wakasugi M.D., Akira Hayakawa M.D. & Hiroshi Ibayashi M.D.

Authors
  1. Takashi Yamauchi M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Akihiro Funakoshi M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hideyuki Wakasugi M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Akira Hayakawa M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hiroshi Ibayashi M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yamauchi, T., Funakoshi, A., Wakasugi, H. et al. Clinical studies on carcinoembryonic antigen in pancreatic cancer. Gastroenterol Jpn 14, 122–128 (1979). https://doi.org/10.1007/BF02773583

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02773583

Key Words

Search

Navigation