Abstract
Lipid derivative of sarcolysin obtained by condensation of sarcolysin with dioleoylglycerol is well retained in the liposome membrane due to high hydrophobic activity exhibits a higher cytotoxic activity than sarcolysinin vitro (CaOv cells) and a much higher antitumor activityin vivo (P388 leukemia). Further increase in the efficacy of the lipid derivativein vivo is attained by incorporating a carbohydrate vector in the liposomal membrane.
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N. A. Rzaeva, F. I. Abdullaev, T. P. Ivanova, and Ya. V. Dobrynin,Eksper. Onkol.,7, No. 6, 67–69 (1985).
Z. P. Sof’inaet al. (Eds.),Experimental Assessment of Antitumor Drugs in the USSR and the USA [in Russian], Moscow (1980).
L. Elkihel, M. Gelin, and Y. Letourneux,Arzneimittelforschung,45, No. 1–2, 190–194 (1995).
K. Hashimoto, J. E. Loader, and S. C. Kinsky,Biochim. Biophys. Acta,816, No. 2, 169–178 (1986).
D. D. Lasic and D. Papahadjopoulos,Science,267, 1275–1276 (1995).
O. Molema and D. C. F. Meijer,Adv. Drug Deliv. Rev.,14, 25–48 (1994).
M. Monsigny, A.-C. Roche, P. Midoux, and R. Mayer,. pp. 1–24.
U. K. Nassander, P. A. Steerenberg, H. Poppe,et al., Cancer Res.,52, No. 2, 646–653 (1992).
R. Perez-Soler,Cancer Treat. Rev.,16, 67–82 (1989).
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Translated fromByulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 123, No. 4, pp. 439–441, April, 1997
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Kozlov, A.M., Korchagina, E.Y., Vodovozova, E.L. et al. Increase in sarcolysin antitumor activity by transforming it into a lipid derivative and incorporation in the membrane of liposomes containing a carbohydrate vector. Bull Exp Biol Med 123, 381–383 (1997). https://doi.org/10.1007/BF02766193
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DOI: https://doi.org/10.1007/BF02766193