Abstract
Compensatory and degenerative structural changes in rat cardiomyocytes are demonstrated. Lipid peroxidation plays a major role in the degenerative processes in the prooxidant zone. In rats with experimental cardiac failure treated with dithiothreitol, compensatory and repair changes predominate in the prooxidant zone cardiomyocytes. Ultrahistochemical analysis shows that administration of dithiothreitol restores ATPase activity of the sarcoplasmic reticulum.
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References
A. Kh. Kogan, N. I. Losev, and A. N. Kudrin,Byull. Eksp. Biol. Med.,101, No. 5, 538–539 (1986).
F. Z. Meerson, V. E. Kogan, Yu. V. Arkhipenko,et al.,Kardiologiya, No. 12, 55–59 (1981).
G. V. Chernyshova, L. B. Stoida, G. G. Amarantova, and I. D. Kuz’mina,Byull. Eksp. Biol. Med.,89, No. 5, 563–565 (1980).
A. Blaustein, L. Schine, W. Brooks,et al., Am. J. Physiol.,250, 595–599 (1986).
I. B. Bukhwalow, I. V. Levandovskii, I. N. Chernysh, and V. B. Sadovnikov,Histochem. J.,24, No. 8, 571 (1992).
S. Curello, C. Ceconi, R. Bigoli,et al., Experientia,41, 42–43 (1985).
D. W. Eley, J. M. Eley, B. Korecky, and H. Fliss,Can. J. Physiol. Pharmacol.,69, 1677–1684 (1991).
I. Fridovich,Science,201, 875–880 (1978).
C. E. Ganote, R. Seabra-Gomes, W. Nayler,et al., Am. J. Pathol.,80, 419–450 (1975).
Y. Gauduel and M. A. Duvelleroy,J. Mol. Cell. Cardiol.,16, 459–470 (1984).
G. Guarnieri, F. Flamigni, and C. M. Caldarera,,12, 797–808 (1980).
J. Hogberg and A. Kristofersonn,Eur. J. Biochem.,74, 77 (1977).
F. Z. Meerson, V. E. Kagan, Y. P. Kozlov,et al., Basic Res. Cardiol.,77, 465–485 (1982).
E. S. Reynolds,J. Cell Biol.,17, 208–212 (1963).
K. Satio, A. Kuroda, H. Tanaka,et al., J. Electron Microsc (Tokyo),42, No. 5, 305–309 (1993).
P. Q. Singal, N. Capoor, K. S. Dhillon,et al., Can. J. Physiol. Pharmacol.,60, 1390–1397 (1981).
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Translated fromByulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 123, No. 4, pp. 399–403, April, 1997
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Chernysh, I.N., Sadovnikov, V.B. Effect of dithiothreitol on cardiomyocyte ultrastructure in the prooxidant zone of rat heart in experimental cardiac failure. Bull Exp Biol Med 123, 344–348 (1997). https://doi.org/10.1007/BF02766182
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DOI: https://doi.org/10.1007/BF02766182