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Loss of carbon dioxide sensitivity by the respiratory system in cats with activated brain GABAergic structures

  • General Pathology And Pathological Physiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Activation of GABAergic system by the agonist sodium oxybutyrate (200 mg/kg body weight) or phenibut (100 mg/kg) results in drastic reduction or complete loss of sensitivity to carbon dioxide by the central regulator of respiration. It is concluded that respiration in this case is regulated by oxygen but not by carbon dioxide.

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Authors and Affiliations

  1. Laboratory of Respiratory Pathophysiology, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow

    I. A. Tarakanov

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  1. I. A. Tarakanov
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Translated fromByulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 123, No. 4, pp. 385–390, April, 1997

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Tarakanov, I.A. Loss of carbon dioxide sensitivity by the respiratory system in cats with activated brain GABAergic structures. Bull Exp Biol Med 123, 331–336 (1997). https://doi.org/10.1007/BF02766179

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  • DOI: https://doi.org/10.1007/BF02766179

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