Skip to main content
SpringerLink
Log in

Effects of blockers of carbohydrate and lipid metabolism on expression of mRNA of some hypothalamic neuropeptides

  • General Pathology And Pathophysiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The effects of single injections of 2-deoxyglucose or 2-mercaptoacetate on the expression of mRNA of neuropeptide Y, pro-opiomelanocortin, and melanin-concentrating hormone in rat hypothalamus were studied byin situ hybridization in order to elucidate the role of these neuropeptides in the mechanisms of alimentary behavior caused by decreased levels of available fatty acids and glucose. The levels of neuropeptide Y mRNA in arcuate nuclei neurons are significantly increased under conditions of glucose deficiency, while the synthesis of melanin-concentrating hormone in the lateral hypothalamic neurons is increased in fatty acid deficiency. These data indicate that glyco- and lipodeprivation are different metabolic signals activating various neuropeptide systems responsible for alimentary behavior.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. A. Akabayashi, C. T. Zaia, I. Silva,et al., Brain Res.,621, 343–348 (1993).

    Article  PubMed  CAS  Google Scholar 

  2. B. B. Baker,Trends Endocrinol. Metab.,5, 120–126 (1994).

    Article  CAS  Google Scholar 

  3. N. Y. Calingasan and S. Ritter,Am. J. Physiol.,250, 546–552 (1994).

    Google Scholar 

  4. L. A. Campfield,Appetite,29, 135–152 (1997).

    Article  PubMed  CAS  Google Scholar 

  5. S. P. Kalra, M. G. Dube, A. Sahu,et al., Proc. Natl. Acad. Sci. USA,88, 10931–10935 (1991).

    Article  PubMed  CAS  Google Scholar 

  6. R. A. Kesterson, D. Huszar, C. A. Lynch,et al., Mol. Endocrinol.,11, 630–637 (1997).

    Article  PubMed  CAS  Google Scholar 

  7. W. Langhans and E. Scharrer,Metabolic Control of Eating, Energy Expenditure and the Bioenergetics of Obesity, Ed. A. P. Simopoulos, Basel (1992), pp. 1–67.

  8. D. S. Ludwig, K. G. Mountjoy, and J. B. Tatro,Am. J. Physiol.,274, 627–633 (1998).

    Google Scholar 

  9. D. Qu, S. S. Ludwig, S. Gammeltoft,et al., Nature,380, 243–247 (1996).

    Article  PubMed  CAS  Google Scholar 

  10. T. Sakurai, A. Amemiya, M. Ishii,et al., Cell,92, 573–585 (1998).

    Article  PubMed  CAS  Google Scholar 

  11. B. G. Stanley, S. E. Kyrkouli, S. Lampert, and S. F. Leibowitz,Peptides,7, 1189–1192 (1986).

    Article  PubMed  CAS  Google Scholar 

  12. J. Wang, A. Akabayashi, H. J. Yu,et al., Brain Res.,804, 7–20 (1998).

    Article  PubMed  CAS  Google Scholar 

  13. N. Zarievski, I. Cusin, R. Vettor, and B. Rohner-Jeanrenaud,Endocrinology,133, 1753–1758 (1992).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Experimental Endocrinology, Endocrinology Research Center, Russian Academy of Medical Sciences, USSR

    V. G. Sergeev & I. G. Akmaev

Authors
  1. V. G. Sergeev
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. G. Akmaev
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated fromByulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 130, No. 8, pp. 180–183, August, 2000

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sergeev, V.G., Akmaev, I.G. Effects of blockers of carbohydrate and lipid metabolism on expression of mRNA of some hypothalamic neuropeptides. Bull Exp Biol Med 130, 766–768 (2000). https://doi.org/10.1007/BF02766089

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02766089

Key Words

Search

Navigation