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Congenital CMV infection in symptomatic infants in Delhi and surrounding areas

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Abstract

Many viral infections are associated with significant maternal and fetal consequences during pregnancy among which cytomegalovirus is one of the most important agent, globally. Both primary and recurrent infection due to this virus can result in fetal infection. Samples from Congenital Anoammaled babies are referred to NICD from Delhi based Government hospitals and surrounding areas for diagnosis of congenital infections like Toxoplasm, Rubella, CMV and Herpes. In the present study, accumulated data is presented for the most common teratogenic virus—Cytomegalovirus prevalence as a causative agent for congenital infection in New Born babies at Delhi and surrounding areas. 96 samples from symptomatic babies in the age group of few days to 6 months exhibiting different congenital anomalies, were reported between 1 st Jan 04 to 30 th April/05. All the blood samples were tested for the detection of CMV (IgM) antibodies using μ-capture ELISA technique. 18(18.75%) samples from babies showed positive titres for CMV-IgM antibodies. None of the mothers of positive babies were found positive for CMV-IgM antibodies but all were serologically exposed to CMV virus previously as their serum samples were positive for CMV-IgG antibodies indicating primary infection in the past or reactivation/reinfection with a different strain of CMV in the early pregnancy.

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References

  1. Trincado DE, Rawlison WD. Congenital and perinatal infection with cytomegalovirus.J Pedia Child Health 2001; 37: 187–92.

    Article  CAS  Google Scholar 

  2. Willison WD, Perry AK, Yow MDet al. Asymptomatic Congenital Cytomegalovirus infection.Am J Dis Child 1990; 144: 1365–1368.

    Google Scholar 

  3. Harris S, Ahlfors K, Ivarsson S, Lermark B, Svanberg L. Congenital Cytomegalovirus infection and sensorineural hearing loss.Ear Hear 1984; 5: 352–355.

    Article  PubMed  CAS  Google Scholar 

  4. Damato EG, Winnen CW. Cytomegalo infection perinatal implications.J Obstet Gynecol Neonatal Nurs 2002; 31: 86–92.

    Article  PubMed  Google Scholar 

  5. Peckam C, Tookay P, Logan S, Giaquinto C. Screening options for prevention of congenital cytomegalovirus infection.J Med Screen 2001; 8: 119–124.

    Article  Google Scholar 

  6. S. Jindal N, Aggarwal A. Apilot seroepidemiological study of cytomegalovirus infection in women of child bearing age.Indian J Med Microbiol 2005; 23: 34–36.

    Article  Google Scholar 

  7. Mathur A, Jindal L Chaturvedi VC. A serological study of cytomegalovirus infection at Lucknow.Ind. J Med Res 1981; 73: 678–681.

    CAS  Google Scholar 

  8. Arvind Rai, S Kumari, S Khare, I Gandhoke, R Bhatia, KK Datta. Maternal Viral Infections and their implications in Congenital defects of new borns.J Basic and Applied Biomedicine 1995; 3(2): 1–9.

    Google Scholar 

  9. Turbadkar D, Mathur M, Rele M, Seroprevalence of Torch Infection in BOH.IJMM 2003; 21: 108–110.

    PubMed  CAS  Google Scholar 

  10. N. Thapliyal, PK Shukla, B. Kumar, S. Upadhyay, G. Jain. TORCH infection in women with bad obstetric history—a piolet study in Kumaon region.Indian J Pathol Microbiol 2005; 48(4): 551–553.

    PubMed  Google Scholar 

  11. A. Chakravarty, B. Kashyap, K. Rathi. The seroepidemiological study on cytomegalovirus in woman of child-bearing age with special reference to pregnancy and maternal-fetal transmission.Indian J Pathol Microbiol 2005; 48(4): 518–521.

    PubMed  Google Scholar 

  12. M. Abraham, P. Abraham, A K Jana, K A Kuruvilla, T. Cherian, P D Moses, E. Mathai, T J John, G. Sridharan. Serology in Congenital Infections: Experience in Selected Symptomatic Infants.Indian Pediatrics 1999; 36: 697–700.

    PubMed  CAS  Google Scholar 

  13. D Trincado, P Palasanthrian, M. Ferson, D. Smith, G. Higgins, M. Catton, A. McGregor, A. Kesson. Congenital Anomalies December 2004; vol. 44(4): A19-A62.

    Article  Google Scholar 

  14. Remington JS, McLeod R, Des onts SG. Inf. Diseases of Fetus and new born infants. Philadelphia.WB Saunder 1995; 140–267

    Google Scholar 

  15. Boppana SB, Rivers LB, Fowler KB, Mach M, Britt WJ. Intrauterine transmission of Cytomegalovirus to infants of women with preconceptional immunity.N Engl J Med 2001; 344: 1366–1371.

    Article  PubMed  CAS  Google Scholar 

  16. Mana Grazia Revello, Maurizio Zavattoni, Milena Furione, Fausto Baldanti and Giuseppe Gerna. Quantification of Human Cytomegalovirus DNA in Amniotic Fluid of Mothers of congenitally Infected Fetuses:Jr Clinical Microbiology Oct. 1999; 37(10) pp. 3350–3352.

    CAS  Google Scholar 

  17. P Hohlfeld, Y Vial, C Maillard-Brignen, B Vaudauxand CL Fawer. Cytomegalovirus fetal infection: prenatal diagnosis.Obstetrics and Gyn 1991; 78: 615–618.

    CAS  Google Scholar 

  18. Friedman S, Ford-Jones EL. Congenital cytomeg ovirus infection: an update.Pediatr Child Health 1999; 4(1): 35–38.

    Google Scholar 

  19. Benjamin Bar-02, Matitahu Berkovitch, Lee Ford-Jones, Gideon Koren. Congenital cytomegalo virus infection. Is there breakthrough?Canadian Family Physician 2001; 47: 1179–1181.

    PubMed  Google Scholar 

  20. Whilley RJ, Cloud G, Gruber W, Storch GA, Demmler GJ, Jacobs RFet al. Ganciclovir treatment of symptomatic congenital cytomegalovirus infection: results of a phase 11 study. National Institute of Allergy and Infectious Diseases. Collaborative Antiviral study Group.J Infect Dis 1997; 175 (5): 1080–1086.

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Microbiology, Directorate General of Health Services, 22 Shamnath Marg, 110054, Delhi

    Inderjeet Gandhoke, Ramesh Aggarwal & Shashi Khare

  2. National Institute of Communicable Diseases, Directorate General of Health Services, 22 Shamnath Marg, 110054, Delhi

    Shiv Lal (Additional DG & Director)

Authors
  1. Inderjeet Gandhoke
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  2. Ramesh Aggarwal
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  3. Shiv Lal
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  4. Shashi Khare
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Correspondence to Shashi Khare.

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Gandhoke, I., Aggarwal, R., Lal, S. et al. Congenital CMV infection in symptomatic infants in Delhi and surrounding areas. Indian J Pediatr 73, 1095–1097 (2006). https://doi.org/10.1007/BF02763052

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