Abstract
Improvement in survival rates of low birth-weight infants particularly in the neonatal intensive care units of India appears to be accompanied by frequent recognition of Necrotizing enterocolitis (NEC) among early survivors. As the philosophy and practice of advanced care for tiny infants becomes more acceptable and affordable in the country, a steady increase in survival of such infants is predictable. However there is growing concern in India that NEC could become a significant contributor to morbidity and mortality in the future. NEC is currently regarded as the most common acquired gastrointestinal emergency in the newborn period, and the outcome of this disease is universally poor. Improved understanding of the pathophysiology and pathogenesis of this condition is required for formulating optimal principles of prevention and management.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Mizrahi A, Barlow O, Berdon W, Blane WA, Silverman W. A Necrotizing Enterocolitis in premature infants.J Pediatr 1965; 66:697–706.
Ryder RW, Shelton JD, Guinan ME. Necrotizing enterocolitis A Prospective Multicenter Investigation.Am J Epidemiol 1980; 112:113–123.
Uauy RD, Fanaroff AA, Korones SB, Philips E, Philips J, Wright L. Necrotizing Enterocolitis in very low birth weight infants: biodemographic and clinical correlates.J Pediatr 1991; 119:630–638.
Covert RF, Neu J, Elliot MJ, Rea JL, Gimotty PA. Factors associated with age of onset of necrotizing enterocolitis.Am J Perinatal 1989;6(4):455–460.
Lucas A, Cole TJ. Breast milk and neonatal necrotizing enterocolitis.Lancet 1990;336:1519–1525.
Kliegman RM. Neonatal necrotizing enterocolitis bridging the basic science with the clinical disease.J Pediatr 1990;117:833–834.
Kleigman RM, Walker WA, Yoken RH. Necrotizing Enterotizing Research Agenda for a Disease of Etiology and Pathogeneis.Paediatric Research 1993;6:34.
Egan EA, Mantilla G, Nelson RM, Eitzman D. A prospective controlled trial of oral kanamycin (in the prevention of) necrotizing enterocolitis.j PEdiatr 1976;89:467–471.
Nowicki PT, Nankervis CA. The role of the circulation in the pathogenesis of necrotizing enterocolitis.Clin Perinatal 1994; 21(2):219–234.
Benirschke K. Necrotizing enterocolitis in the newborn infant Report of 68th Ross Conference on Pediatric Research Columbus, Ohio, Ross Laboratories 1974: 27.
Yu Victor YH, Tudenope David I. Neonatal Necrotizing Enterocolitis: 2: Perinatal Risk Factors.Med J Aust 1977;1:688–693.
Wiswell TE, Robertson CF, Jones TA, Tuttle DJ. Necrotizing enterocolitis in full-term infants. A case-control study.Am J Dis Child 1998;142 (5):532–535.
Caplan MS, Kelly A, Hsueh W. Endotoxin and hypoxia induced intestinal necrosis in rats: the role of platelet activating factor.Pediatr Res 1992;31:428–434.
Halac E, Halac J, Begue EFet al. Prenatal and postnatal corticosteroid therapy to prevent neonatal necrotizing enterocolitis: a controlled trial.J Pediatr 1990;117:132–138.
Bell MJ, Tearberg JL, Feigch RDet al. Neonatal necrotizing enterocolitis. Therapeutic decisions based upon clinical staging.Ann Surg 1978;187(1):1–7.
Walsh MC, Kleigman RM. Necrotizing enterocolitis: Treatment based on staging criteria.Pediatr Clin North Am 1986;33:179–201.
Maalouf EF, Fagberni A, Duggan Pet al. Magnetic resonance imaging of intestinal necrosis in preterm infants.Abstr Hot Topics in Neonatology.
Samaniego Munoz M, Sanchez Navarro MR, Serum CK BB. A biochemical marker in neonatal necrotizing enterocolitis.An Esp Pediatr 1996;44(6):577–580.
Kosloske AM. SuRgery of necrotizing enterocolitis.World J Surg 1985;9:277–284.
Kleigman RM, Fanaroff AA. Neonatal necrotizing enterocolitis a nine year experience (II) Outcome assessment.Am J Dis Child 1981;135(7):608–611.
Chaco J, Ford WDA, Haslam R. Growth and neurodevelopmental outcome in extremely-low-birth-weight infants after laparotomy.Pediatr Surg Int 1999;15:1–4.
Vasan U, Sotoff SP. Prevention of Neonatal Necrotizing Enterocolitis clinics.Perinatology 1994;21(2):425–435.
Bury RG, Tadehope. Enteral antibiotics for preventing Necortizing Entercolitis in low birth weight or preterm infants.Cochrane Database Syst Rev 2000; 2: CD 000405.
Crowley P, Chalmers I, Keines JNCet al. The effects of corticosteroid administration before delivery: Overview of the evidence from controlled trials.Br J Obstet Gyanecology 1990; 97:11–17.
Carver JD, Barness CA. Trophic factors for the gastrointestinal tract.Clin Perinatol 1996;23(2):265–285.
Neu J, Roig JC, Mectze WHet al. Enteral glutamine supplementation for very low birth weight infants decreases morbidity.J Pediatr 1997;131:691–694.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Kulkarni, A., Vigneswaran, R. Necrotizing enterocolitis. Indian J Pediatr 68, 847–853 (2001). https://doi.org/10.1007/BF02762112
Issue Date:
DOI: https://doi.org/10.1007/BF02762112