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Evaluation of clinico-immunological parameters in pediatric ABPA patients

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Abstract

Allergic bronchopulmonary aspergillosis patients (ten in the age group 5–13) were studied with respect to clinical and immunodiagnostic tests. All the patients showed wheal and flare reaction withA. fumigatus antigens. Clinical features included bilateral infiltration and hilar lymphadenopathy. Eosinophilic count in these patients was observed to be in the range of 300–2500/mm3. Sera of six patients indicated precipitin reaction withA. fumigatus antigens. An elevated total serum IgE was noticed in all the patients.A. fumigatus specific IgG and IgE antibodies were increased in these patients. Optical density of the sera of all the patients against controls were observed to be in the range of (0.426 to 1.8 for IgG and 0.147 to 0.562 for IgE) by ELISA. Western blot analysis indicated that there may be correlation between the clinical stages of the disease and immunological reactivity of the sera with various antigenic components.

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Authors and Affiliations

  1. CSIR Centre for Biochemicals, Mall Road, University Campus, Near Jubilee Hall, 110 007, Delhi

    B. Banerjee, A. P. Joshi & P. Usha Sarma

  2. Pediatric Chest Clinic, All Indian Institute of Medical Sciences, New Delhi

    S. Roy

Authors
  1. B. Banerjee
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  2. A. P. Joshi
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  3. P. Usha Sarma
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  4. S. Roy
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Banerjee, B., Joshi, A.P., Usha Sarma, P. et al. Evaluation of clinico-immunological parameters in pediatric ABPA patients. Indian J Pediatr 59, 109–114 (1992). https://doi.org/10.1007/BF02760911

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