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Circadian rhythms of salivary cortisol content during long-term space flight

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Abstract

Adaptation mechanisms of adrenal function related to secretion of cortisol were studied under conditions of microgravity. Parameters of diurnal rhythms of salivary cortisol were studied by Russian cosmonauts on board orbital station Mir during long-term space flights (SF). The preflight circadian rhythms of salivary cortisol in cosmonauts were characterized by the morning maximum occurring at 9∶43 a.m., the fluctuation amplitude 6.05 nmol/1, and the daily average concentration 8.79 nmol/l. The characteristics of cortisol diurnal rhythm changed under conditions of long-term space flight. On average, the rhythm measure and amplitude decreased after two months of flight. The postflight maximum concentration of free cortisol tended to occur later in the day. Evidently, the motor activity during SF, i.e., prophylactic exercises along with other factors, significantly influenced the parameters of cortisol circadian rhythm that was revealed by the individual variability of findings during the flight. After the long-term SF, individual ratios of salivary and plasma cortisol levels increased against the background of increased plasma content of the hormone, i.e., the fraction of free, physiologically active hormone in the total pool of circulating molecules decreased.

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Authors and Affiliations

  1. National Research Center of the Russian Federation Institute of Medico-Biological Problems, Moscow, Russia

    I. M. Larina & T. M. Smirnova

  2. L. Johnson NASA Space Center, Houston, Texas, USA

    P. Witson & Yu-Ming Chen

Authors
  1. I. M. Larina
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  2. P. Witson
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  3. T. M. Smirnova
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  4. Yu-Ming Chen
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Larina, I.M., Witson, P., Smirnova, T.M. et al. Circadian rhythms of salivary cortisol content during long-term space flight. Hum Physiol 26, 462–467 (2000). https://doi.org/10.1007/BF02760276

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  • DOI: https://doi.org/10.1007/BF02760276

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