Abstract
The inner cytosine methylation was analyzed in the CCWGG sequences of the 5′-terminal region of the human calcitonin gene from peripheral blood and bone marrow cells in various forms of leukemia. Since these sequences remain nonmethylated both in the norm and in various leukemia forms, the CpG dinucleotide hypermethylation of the 5′-end of the human calcitonin gene, characteristic for the development of leukemias, does not spread to adjacent CpNpG sequences.
Abbreviations
- CT:
-
calcitonin
References
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Buryanov, Y.I., Shevchuk, T.V., Zakharchenko, N.S. et al. The absence of the CpNpG methylation at the 5′-terminal region of the human calcitonin gene in norm and leukemias. Russ J Bioorg Chem 26, 358–360 (2000). https://doi.org/10.1007/BF02759290
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DOI: https://doi.org/10.1007/BF02759290