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Synthesis and study of the effect of uracil and theophylline derivatives on the glucose transport into rat hepatic cells

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Abstract

A series of uracil and theophylline derivatives was synthesized. 4-Amino-1,3-dimethyl-5-non-anoylaminouracil displayed the most pronounced effect of thein vitro stimulation of the 2-deoxyglucose transport into hepatic rat cells.

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Abbreviations

BSA:

bovine serum albumin

HEPES:

N-(2-hydroxyethyl)piperazine-N′-(2-ethanesulfonic acid)

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Authors and Affiliations

  1. Institute of Biological Medicine, ul. Akad. Oparina 4, 117815, Moscow, Russia

    O. N. Leonov, M. L. Tsyrenina, E. I. Melnik, V. M. Devichenskii & L. Yu. Kryukova

  2. Center of Medical, Biological, and Ecological Problems, Russian Academy of Natural Sciences, Simferopolskii bulvar 8, 113149, Moscow, Russia

    E. A. Vorontsov, S. L. Kuznetsov & L. N. Kryukov

Authors
  1. O. N. Leonov
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  2. M. L. Tsyrenina
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  3. E. I. Melnik
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  4. V. M. Devichenskii
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  5. L. Yu. Kryukova
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  6. E. A. Vorontsov
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  7. S. L. Kuznetsov
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  8. L. N. Kryukov
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Deceased.

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Leonov, O.N., Tsyrenina, M.L., Melnik, E.I. et al. Synthesis and study of the effect of uracil and theophylline derivatives on the glucose transport into rat hepatic cells. Russ J Bioorg Chem 26, 334–336 (2000). https://doi.org/10.1007/BF02759286

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  • DOI: https://doi.org/10.1007/BF02759286

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