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The synthesis and antioxidant activity of azole derivatives of hemin

Abstract

New derivatives of proto- and deuterohemin IX containing tri- and tetrazole rings were synthesized and characterized. A pronounced antioxidant activity was found for these compounds in the Fe(II)/ascorbate-dependent system of lipid peroxidation in murine liver homogenates.

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Abbreviations

HOBt:

1-hydroxybenzotriazole

LPO:

lipid peroxidation

MDA:

malondialdehyde

NTB:

Nitrotetrazolium Blue

P-Fe:

ferric porphyrinate

TPP:

tetraphenylporphyrin

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Correspondence to E. A. Rozhkova.

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Rozhkova, E.A., Lysko, A.I., Kuleshov, K.V. et al. The synthesis and antioxidant activity of azole derivatives of hemin. Russ J Bioorg Chem 26, 419–422 (2000). https://doi.org/10.1007/BF02758671

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  • DOI: https://doi.org/10.1007/BF02758671

Key words

  • hemin
  • azoles
  • synthesis
  • antioxidant activity
  • lipid peroxidation
  • liver homogenates