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TheS,X-acetals in nucleoside chemistry: II. The synthesis of 3′-O-methylthiomethylribonucleosides

Abstract

3′-O-Methylthiomethyl derivatives of ribonucleosides were synthesized from the selectively protected nucleosides by the action of a dimethyl sulfide-benzoyl peroxide mixture in acetonitrile or a dimethyl sulfoxide-acetic anhydride-acetic acid mixture.

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Correspondence to S. G. Zavgorodny.

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For communication I, see [1].

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Pechenov, A.E., Zavgorodny, S.G., Shvets, V.I. et al. TheS,X-acetals in nucleoside chemistry: II. The synthesis of 3′-O-methylthiomethylribonucleosides. Russ J Bioorg Chem 26, 407–413 (2000). https://doi.org/10.1007/BF02758669

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  • DOI: https://doi.org/10.1007/BF02758669

Key words

  • ribonucleosides
  • methylthiomethylation
  • thioacetals
  • Pummerer’s rearrangement