Abstract
The treatment of children with short stature was revolutionized by the creation of recombinant growth hormone therapy. While it cannot be denied that therapy adds significant height to children who are growth hormone deficient, such treatment is both painful, requiring many injections for years, as well as extremely expensive, both for the children's parents as well as for medical health care for society. With the indications for growth hormone treatment expanding over the years to include children with short stature who are not growth hormone deficient, it is important to determine all potential benefits beyond the obvious physical effects in order to make efficient cost-benefit determinations on appropriate usage of growth hormone therapy. One aspect of possible benefits for these children with short stature may be psychological features, such as increased overall happiness and self-esteem that is gained with increased height. A review and analysis of literature was undertaken in order to determine what effect, if any, growth hormone therapy has on short children's psychosocial wellbeing.
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References
Steinhausen H, Stahnke N. Psychendocrinological studies in dwarfed children and adolescents.Arch Dis Child 1976; 51: 778–783.
Bjork S, Jonsson B, Westphal O, Levin J-E. Quality of life of adults with growth hormone deficiency: a controlled study.Acta Paediatr Scand 1989; 356 (Suppl): 55–59.
Stabler B, Clopper RR, Siegel PT, Stoppani C, Compton PG, Underwood LE. Academic achievement and psychological adjustment in short children.J Dev Behav Pediatr 1994; 15: 1–6.
Erling A, Wiklund I, Wikland K. Psychological functioning in boys of short stature: effects of different levels of growth hormone secretion.Acta Paediatr 2002; 91: 966–971.
Abelson JL, Glitz D, Cameron OG, Lee MA, Bronzo M, Curtis GC. Blunted growth hormone response to clonidine in patients with generalized anxiety disorder.Arch Gen Psychiatr 1991; 48(2): 157–162.
Barker DJ, Erikkson JG, Forsen T, Osmond C. Infant growth and income 50 years later.Arch Dis Child 2005; 90(3): 272–273.
van Pareren, YK, Duivenvoorden FS, Slijper FS, Koot HM, Hokken-Koelega AC. Intelligence and psychological functioning during long-term growth hormone therapy in children born small for gestational age.J Clin Endocrinol Metab 2004; 89(11): 5295–5302.
Wiren L, Johnannson G, Bengtsson B. A prospective Investigation of quality of life and psychological well-being after the discontinuation of GH treatment in adolescent patients who had GH deficiency during childhood.J Clin Endocrinol Metab 2001; 86(8): 3494–3498.
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Zlotkin, D., Varma, S.K. Psychosocial effects of short stature. Indian J Pediatr 73, 79–80 (2006). https://doi.org/10.1007/BF02758266
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DOI: https://doi.org/10.1007/BF02758266