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A clinical trial of broxyquinoline—brobenzoxalidine in childhood diarrhoea

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Summary and Conclusions

A controlled clinical trial was undertaken for assessing the usefulness of routine administration of broxyquinoline-brobenzoxaldine in the management of childhood diarrhoea. Ninety-seven patients with gastro-enteritis and 11 with bacillary dysentery received the trial drug while, as control, 94 patients with gastro-enteritis received only kaolin powder and 10 patients with dysentery received sulphonamides. The other management was similar in the two groups. The cases were randomly distributed in the two groups. The two groups were matched for severity of the disease. The results were compared using various parameters and subjected to statistical analysis. It was concluded that the routine use of broxyquinoline-brobenzoxaldine in the management of gastro-enteritis did not improve the results. In the patients with dysentery, the trial drugs appeared to give better results than sulphonamides. It is felt that in trials of this nature, patients with positive bacterial stool cultures should be studied separately.

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Authors and Affiliations

  1. Baroda

    A. P. Shah & Arun T. Phatak

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  1. A. P. Shah
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  2. Arun T. Phatak
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From the Department of Pediatrics, Medical College and S.S.G. Hospital, Baroda.

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Shah, A.P., Phatak, A.T. A clinical trial of broxyquinoline—brobenzoxalidine in childhood diarrhoea. Indian J Pediatr 40, 83–92 (1973). https://doi.org/10.1007/BF02753456

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  • DOI: https://doi.org/10.1007/BF02753456

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