Summary
The current literature regarding idiopathic vesical lithiasis is reviewed. A concept that it is a neonatal disease appears to be emerging from these studies. It is probable that the stone embryo is formed in the kidney during this vulnerable period by a deficiency of factors, and that subsequently the embryo stone grows in the bladder. Some advance has also been made in recognition of the factors which are deficient. It appears from Van Reen’s work that it may be a form of protein malnutrition with specific deficiency of sulphur containing amino acids. In endemic areas of stone disease, further studies need to be undertaken keeping in view the above findings.
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References
Anderson, D. A., Sriramachari, S. and Khandagale, M. K. (1963). Investigations into relationships between bladder stones and malnutrition.Indian. J. Med. Sc. 17, 617.
Anderson, L. and McDonald, J. R. (1946). The origin, frequency and significance of microscopic calculi in the kidney.Surg. Gynae. 82, 275.
Aurora, A. L. (1960). Thesis for M.Sc., Pathology, All India Institute of Medical Sciences, New Delhi.
Aurora, A. L. (1964). Thesis for Ph.D., Pathology, Delhi University.
Aurora, A. L., Ramalingaswami, V. and Gaitonde, P. D. (1964). Bladeer stone disease in children in Delhi area.J. Urol. 91, 347.
Boyce, W. H. and King, J. S. Jr. (1963). Recent concepts concerning the origin of matrix and stones.Ann. New York Acad. Sc. 104, 539.
Borden, T. A. and Vermeulen, C. W. (1966). The renal papilla in calculogenesis of oxamide stones.Invest. Urol. 4, 125.
Coburn, S. P. and Packett, L. V. Jr. (1962). Calcium phosphate and citrate interactions in oxalate urolithiasis produced with a low phosphate diet in rats.J. Nutr. 76, 385.
Dhanmitta, S., Valyasevi, A. and Van Reen, R. (1967). Studies of bladder stone disease in Thailand. IX. Effect of orthophosphate and fat free powdered milk supplementations on the occurrence of cystalluria.Amer. J. Clin. Nutr. 20, 1387.
Dhira, S. Comer (1967). Quoted by Van Reen. (1962).
Eckstein, H. B. (1961). Endemic urinary lithiasis in Jewish children. A clinical study of 119 cases.Arch. Dis. Childh. 36, 137.
Elliot, J. S. (1965). Urinary calculus disease.Surg. Clin. N. Amer. 45, 1292.
Elliot, J. S. and Eusebio, E. (1961). Calcium oxalate solubility, the effect of organic salts, urea, creatine and organic acid.Invest. Urol. 3, 72.
Idem. (1961). The effect of urinary amino acids upon the solubility of calcium oxalate.Invest. Urol. 2, 428.
Idem. (1967). Calcium oxalate solubility. The effect of tracer metals.Invest. Urol. 4, 428.
Fleisch, H. and Bisaz, S. (1962). Isolation from urine of pyrophosphate, a calcification inhibitor.Amer. J. Physiol. 203, 671.
Flock, R. H. (1929). Calcium and phosphorus excretion in the urine of patients with renal or ureteric calculi. J.A.M.A.113, 1466.
Gershoff, S. N. Faragalla, F. F., Nelson, D. A. and Andrus, S. B. (1959). Vitamin B, deficiency and oxalate nephrocalcinosis in the cat.Amer. J. Med. 27, 72.
Gershoff, S. N. and Prien, E. L. (1960). Excretion of urinary metabolities in calcium oxalate lithiasis. Effect of tryplophane and vitamin B6 administration.Amer. J. Clin. Med. 8, 812.
Gershoff, S. N., Pren, E. L., and Chandraponand, A.j. (1963). Urinary stores in Thailand.J. Urol. 90, 285.
Halstead, S. B. (1961), Bladder stones in Thailand. A review of the problem.Amer. J. Trop. Med. & Hyg. 10, 218.
Halstead, S. B. and Valyasevi, A. (1967). Studies of bladder stone disease in Thailand. III. Epidemiological studies in Ubol province.Amer. J. Clin. Nutr. 20, 1329.
Halstead, S. B., Valyasevi, A. and Umparit, P. (1967a). Studies of bladder stone disease in Thailand. V. Dietary habits and disease prevalence.Amer. J. Clin. Nutr. 20, 1329.
Hamersten, G. (1936). Quoted by McGeown and Bull. (1967).
Hammersten, G. (1929). Quoted by Elliot and Euselsio. (1965)..
Hodgkinson, A., Pyrah, L. N. (1958). The urinary excretion of calcium and inorganic phosphate in 344 patients with calcium stones of renal origin. Brit. J. Surg.46, 16.
Howard, J. E. (1962). Urinary stones.Canad. Med. Assoc. J. 68, 1001.
Lyon, E. S., Borden, T. A., Ellis, Jr. and Vermeulen, C. W. (1966). Calcium oxalates lithiasis produced by pyridoxine deficiency and inhibition with magnesium diet.Invest. Urol. 4, 133.
Lyon, E. S., Borden, T. A. and Vermeulen, C. W. (1966a). Experimental oxalate lithiasis produced with lethylene glycol,Ibid. 4, 143.
McCarrison, R. (1931). A lecture on the causation of stone in India.Brit. Med. J. 1, 1009.
McGeown, M. G. and Bull, G. M. (1957). The pathogenesis of urinary calculus formation.Brit. Med. Bull. 13, 53.
Modlin, M. (1967). The aetiology of renal stone. A new concept arising from studies on a stone free population.Ann. Roy. Coll. Surg. 40, 155.
Modlin, M. (1968). Personal communication.
Morris, P. G. and Steenbock, H. (1951). Citrate lithiasis in rat.Amer. J. Physiol. 167, 698.
Osborne, T. B., Mendel, L. B. and Ferry, E. L. (1917). The incidence of phosphate urinary calculi in rats fed on experimental rations.J.A.M.A. 69, 32.
Passmore, R. (1953). Observations on the epidemiology of stone in bladder in Thailand.Lancet.1, 638.
Ramalingaswami, Y. and Aurora, A. L. (1961). Nutritional aspects of calculus disease of the urinary tract.Fed. Proc., 20 Pt, III, Suppl. 7, 317.
Sanong, U. (1958). Study of urinary calculi in Thailand.Med. J. Thailand,1, 30.
Sagar, R. H. and Spargo, B. (1955). The effect of a low phosphate ration calcium metabolism in the rat with the production of calcium citrate urinary calculi.Metabolism 4, 519.
Schorr, E., Almy, T. B., Sloan, M. H., Taussky, H. and Toscani, V. (1941). The relation between the urinary excretion of citric acid and calcium and its implications for urinary stone formation.Science,96, 587.
Snell, E. E. (1954). Vitamin adequacy and specific metabolic functions. Methods for evaluation of nutritonal adequacy and status.Natl. Acad. Sci. Res. Council Publ. Washington D. C. p. 89.
Valyasevi, A., Hatstead, S. B., Pantuwatna, S. and Tankaypul, C. (1967). Studies of bladder stone disease in Thailand. Dietary habits, nutritional intake, and infant feeding practices among residents of a hypo- and hyperendemic area.Amer. J. Clin. Nutr. 20, 1340.
Valyasevi, A. Halstead, S. B. and Dhanuntta, S. (1967a). Bladder stone disease in Thailand. VI. Urinary studies in children 2–10 years old resident in a hypo- and hyperendemic area.Amer. J. Clin. Nutr. 20, 1362.
Valyasevi, A. and Dhanuntta, S. (1967b). Studies of bladder stone disease in Thailand. VII. Urinary studies in newborn and infants of hypo-and hyperendemic areas.Amer. J. Clin. Nutr. 20, 1369.
Van Reen, R. H., Lyon, H. W. and Losee, F. L. (1959). Urolithiasis in the rat. I. The influence of diet on the formation and prevention of calcium citrate calculi.J. Nutr. 69, 392.
Van Reen, R. H. (1962). Urolithiasis in the rat. III. Effects of protein, carbohydrate, phosphate on occurrence of calcium citrate stones. J. Nutr.77, 137.
Van Reen, R. H., Valyasevi, A. and Dhanuntta, S. (1967). Studies of blader stone disease in Thailand. VIII. Sulfate excretion by newborns and infants. Possible relationship of protein malnutrition to bladder stone disease.Amer. J. Clin. Nutr. 20, 1378.
Vermeulen, C. W., Lyon, E. S. and Gill, W. B. (1964). Artificial urinary concretions.Invest. Urol. 1, 370.
Vermeulen, C. W., Lyon, E. S., Borden, T. A. (1966). The renal papilla and the genesis of urinary calculi.Ibid. 58, 30.
Yarbro, C. L. (1958). Studies on the solubility of tricalcium phosphate in urine. IV. Effect of citrate.J. Urol. 80, 383.
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From the Department of Pediatrics, All India Institute of Medical Sciences, New Delhi-16.
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Verma, I.C. Idiopathic vesical lithiasis in children—Some recent concepts. Indian J Pediatr 35, 502–509 (1968). https://doi.org/10.1007/BF02753126
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DOI: https://doi.org/10.1007/BF02753126