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Serum creatine phosphokinase (CPK) Isoenzymes in perinatal asphyxia

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Abstract

Two newborn infants with perinatal asphyxia are described in whom serum levels of all three isoenzymes (MM, MB and BB) of creatine phosphokinase (CPK) were elevated. The possible mechanism of production and the implications of these findings are discussed, and it is suggested that caution must be exercised in utilizing these data to predict either the immediate prognosis or the longterm outcome in individual infants.

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References

  1. Rudolph N and Gross RT: Creatine phosphokinase activity in serum of newborn infants as an indicator of fetal trauma during birth. Pediatrics 38:1039, 1966

    PubMed  CAS  Google Scholar 

  2. Cao A, Trabalza N, Ds Virgiliis S, Furbetta M, Coppa G: Serum creatine kinasc activity and serum creatine kinase isoenzyrnes in newborn infants. Biol Neonate 7:126. 1971

    Google Scholar 

  3. Gilboa N, and Swanson JR: Serum creatine phosphokinase in normal new-borns. Arch Dis Child 51:283, 1976

    PubMed  CAS  Google Scholar 

  4. Nelson RM, Bucciarelli RL, Eitzman DV, Egan EA and Gessner IH: Serum creatine phosphokinase MB fraction in new-born infants with transient tricuspid insufficiency. N Engl J Med 298:146, 1978

    Article  PubMed  CAS  Google Scholar 

  5. Donnelly WH, Bucciarelli RL, and Nelson RM: Myocardial necrosis in stressed newborns. Pediat Res (Abstracts) 12:380, 1978

    Article  Google Scholar 

  6. Becker M and Menzel K: Brain typical creatine kinase in the serum of newborn infants with perinatal brain damage. Acta Paediatr Scand 67:177, 1978

    Article  PubMed  CAS  Google Scholar 

  7. Shields WD, Feldman R, and Watanabe K: Creatine kinase BB isoenzyme and intra-ventricular hemorrhage in preterm infants. Clin Res (Abstract) 27:122A, 1979

    Google Scholar 

  8. Rosalki SB: An improved procedure for serum CPK determinations. J Lab Clin Med 69:696, 1967

    PubMed  CAS  Google Scholar 

  9. Zsigmond EK, Starkweather WH, Duboff GS and Flynn KA: Elevated serum creatine phosphokinase activity in a family with malignant hyperpyrexia. Anaesth Analg (Paris) 2:827, 1972

    Google Scholar 

  10. Somer H, Kaste M, Troupp H, and Konttinen A: Brain creatine kinase in blood after acute brain injury. J Neurol Neurosurg Psychiat 38:572, 1975

    Article  PubMed  CAS  Google Scholar 

  11. Mercer DW: Frequent appearance of creatine kinase isoenzyme BB in sera of critical care patients. Clin Chem 23:611, 1977.

    PubMed  CAS  Google Scholar 

  12. Coolen RB, Pragay DA, and Chilcote ME: The occurrence of the brain (BB) isoenzyme of serum creatine kinase (CK) in different diseases as determined by quantitative electrophoresis and ion exchange column chromatography. Clin Chem 21: 976, 1975

    Google Scholar 

  13. Laboda HM, and Britton VJ: Creatine kinase isoenzyme activity in human placenta and in serum of women in labor. Clin Chem 23:1329, 1977

    PubMed  CAS  Google Scholar 

  14. Nealon DA. and Henderson AR: Measurement of brain specific creatine kinase isoenzyme activity in serum. Clin Chem 21:1663, 1975

    PubMed  CAS  Google Scholar 

  15. Chopin N, Lavaud J, Voyer M, Bailly M, Cloup M.: Creatine kinase serique BB dans la souffrance cerebrale du nouveaune. Ann Biol clin 38:345, 1980

    CAS  Google Scholar 

  16. Cuestas, Raul A Jr.: Creatine Kinase Isoenzymes in High Risk Infants. Pediatr Res 14:935, 1980

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Departments of Pediatrics and Pathology, Downstate Medical Center, State University of New York, USA

    M. M. Thangavel M.B.B.S., P. L. Chordia M.D. & N. Rudolph M.B.B.Ch.

Authors
  1. M. M. Thangavel M.B.B.S.
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  2. P. L. Chordia M.D.
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  3. N. Rudolph M.B.B.Ch.
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Thangavel, M.M., Chordia, P.L. & Rudolph, N. Serum creatine phosphokinase (CPK) Isoenzymes in perinatal asphyxia. Indian J Pediatr 49, 761–765 (1982). https://doi.org/10.1007/BF02752665

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  • DOI: https://doi.org/10.1007/BF02752665

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