Abstract
Five hundred children below the age of 12 years suffering from lung tuberculosis viz., primary complex (PC) or progressive primary complex (PPC) were studied. Diagnosis was based on Kenneth Jones criteria; selected cases having score of 5 or more. One hundred and eighty cases of PC were given A-1 (6 RH) regimen, while 312 cases of PPC were given A-2 (2SHRZ/4 RH) or A-3 (2 SRH/4 RH) or A-4 (2 RHE/4 RH) regimen. Follow-up was done for 6 months after completing the treatment to observe the relapse rate. In cases of PC, 6 RH regimen appeared adequate and cheaper with no relapse rate. In cases of PPC with short course chemotherapy, compliance of patients had been very good. Relapse rate was upto 13% which is acceptable. Drug toxicity was very low.
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References
Bhandari NR, Kaul KK. Problems in primary tuberculosis in children.Indian J Child Health 1961; 10: 549–551.
Achar ST.Textbook of Pediatrics in Developing Tropical Countries, 2nd edn. New Delhi: Orient Longman, 1985.
Stegen G, Kenneth J, Kaplan P. Criteria for guidance in the diagnosis of tuberculosis.Pediatrics 1969; 43: 260–263.
Dingley HB. Short term chemotherapy in children.Indian Tuberculosis 1980; 28: 100–102.
Prasad BG. Socioeconomic classification (revised).J Indian Med Assoc 1970; 55: 198–201.
Panchatcharam M, John E, Raj CM, Santhanakrishnan BR. Radiological criteria for the diagnosis of pulmonary forms of tuberculous infection.Indian Pediatr 1985; 52: 357–363.
Patel GR.Diagnosis of Tuberculosis in Children by Modified KJ Criteria. Dissertation submitted to Gujarat University, March 1979.
Rakhit A, Khandelwal PG, Mukherjee SK, Dey AK. Intensive short course chemotherapy in pulmonary tuberculosis.Indian Pediatr 1986; 53: 243–248.
Bhakoo ON, Gupte SP. Tuberculosis in children.Indian J Pediatr 1969; 36: 65–67.
Shyam R, Karen S, Reddi YR, Chandra H. A study of chronic pulmonary tuberculosis in childhood. Indian Pediatr 1971; 8: 335–338.
Ramchandran RS. Some aspects of tuberculosis in children: 3000 cases.Mediscope, 1971; 14: 5.
Mathur HC, Saxena S, Bharadwaz RM. Evaluation of KJ criteria for diagnosis of childhood tuberculosis.Indian Pediatr 1974; 41: 349–355.
Manchanda SS. Childhood tuberculosis.J Indian Med Assoc 1961; 10: 510–524.
Udani PM. Incidence of tuberculosis in children.Indian J Child Health 1961; 10: 510–524.
Raju SC, Shah PR, Desai AB. Diagnosis of tuberculosis in children.Medicine and Surgery 1983; 23 (8): 17–22.
Desai AB, Vani G, Ahya PN. Diagnostic value of BCG in childhood tuberculosis.Indian Pediatr 1972; 9: 767–771.
Aiyar B, Shekhri R. Diagnostic value of BCG vaccination.J Pediatr Clin India 1973; 8: 17–20.
Dixit KP, Singh S. BCG test for diagnosis of tuberculosis.Indian Pediatr 1986; 13: 687–688.
Second East African/British Medical Research Council Study. Controlled clinical trial of four 6-month regimens of chemotherapy for pulmonary tuberculosis.Am Rev Res Tory Dis 1976; 114: 471–473.
Seth V. Antituberculosis therapy in children.Indian Pediatr 1966; 53: 179–198.
British Thoracic and Tuberculosis Association. Short course chemotherapy in pulmonary tuberculosis: a controlled trial.Lancet 1976; 2: 1102–1104.
Varudkar BL. Short course chemotherapy for tuberculosis in children.Indian Pediatr 1985; 52: 593–597.
Madhukar SD, Kulkarni VV, Patel PR. Comparative evaluation of different chemotherapeutic regimes in childhood tuberculosis.Indian Medical Association 1961; 36: 141–142.
Michael RD, Pharm D. Clinical pharmacology of antitubercular drugs.Pediatr Clinic North Am 1983; 30: 177–191.
O'Brien RJ, Long MW, Cross FS et al. Hepatotoxicity from INH and Rifampicin among children treated for tuberculosis.Pediatrics 1983; 72: 491–499.
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Shah, P.R., Ramakrishna, B., Mehta, D.K. et al. Pulmonary tuberculosis in ahmedabad: Epidemiology, diagnosis and short course chemotherapy. Indian J Pediatr 59, 435–442 (1992). https://doi.org/10.1007/BF02751558
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DOI: https://doi.org/10.1007/BF02751558