Abstract
Hepatitis B antigenemia has been associated and implicated in many glomerular diseases. One hundred and ten children with glomerulonephritis were taken up for the study. HBs Ag and Anti HBs were estimated. 52% of children were positive for HBV markers. Preceding jaundice, hypertension, hematuria were seen more in children with HBV markers. Children with acute nephritic syndrome recovered spontaneously. A higher relapse rate and steroid resistance were seen in nephrotics with HBV markers. Histologically, membranous nephropathy and membranoproliferative glomerulonephritis were seen mainly in children who were HBs positive.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Blumberg BS, Alter HJ, Visnich S. A new antigen in leukaemic sera.JAMA 1965;191: 541–546
Combes B, Stastny P, Shorey J, et al. Glomerulonephritis with deposition of Australian antigen—antibody complexes in GBM.Lancet 1971;ii: 234–237
Brzosko WT, Krawzynski K, Nazarewicz KT, Morzycka M, Nowoslawski A. Glomerulonephritis associated with HBs Ag immune complexes in children.Lancet 1974;ii: 478–482
Takekoeshi Y, Tanaka M, Shida N, Satake Y, Saheki Y, Matsumoto S. Strong association between membranous nephropathy and HB surface antigenaemia in Japanese children.Lancet 1978;ii: 1065–1068
Kleinknecht C, Levy M, Peix A, Broyer M, Courtecusse V. Membranous glomerulonephritis and hepatitis B surface antigen in children.J Pediatr 1979;95: 946–952
Myeres BD, Griffel B, Navek D, Jankielowitz T, Klajman A. Membrano proliferative glomerulonephritis associated with persistent viral hepatitis.Am J Clia Pathol 1973;60: 222–228
Eknoyan G, Gyorkey F, Dischoso, et al. Renal morphological and immunological changes associated with acute viral hepatitis.Kidney Int 1972;1: 413–419
Wiggelinkhuizen J, Sinclair-Smith C, Stannard LM, Smuts H. Hepatitis B virus associated membranous glomerulonephritis.Arch Dis Child 1983;58: 488–496
McCollum RW, Zuckerman AJ. Viral hepatitis. Report on a WHO informal consultation.J Med Virol 1981;8: 1–29
General incidence of HBV markers: Data from P.G. Institute of Basic Medical Sciences
Nagy J, Bajtai G, Brasch H, et al. The role of Hepatitis B surface antigen in the pathogenesis of glomerulopathies.Clin Nephrol 1979;12: 109–116
Vos GM, Grobbelaar BG, Milner LV. A possible relationship between persistent hepatitis B antigenemia and renal disease in Southern African Bantu.S Afr Med J 1973;47: 911–912
Hsu HC, Lin GH, Chang MH, Chen CH. Association of HBs Ag and membranous nephropathy in children in Taiwan.Clin Nephrol 1983;20: 121–129
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nammalwar, B.R., Sankar, V.S., Ramesh, S. et al. Hepatitis B virus infection and glomerulonephritis. Indian J Pediatr 54, 759–763 (1987). https://doi.org/10.1007/BF02751299
Issue Date:
DOI: https://doi.org/10.1007/BF02751299