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Chorionic villus sampling for first-trimester fetal diagnosis: preliminary experience

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Abstract

Chorion biopsy was performed in 110 cases at 6–12 weeks of pregnancy, following an ultrasonic chorion frondosum localization. 100 cases had their biopsies taken immediately before induced abortion and in 10 cases, biopsy was performed for genetic reasons. Chromosomal analysis by direct preparation was carried out in 108 cases. Enzyme assay was carried out in 40 cases for β-Galactosidase, α-glucosidase, α-galactosidase, β-glucoronidase and arylsulphatase. The possibility is discussed that the present approach may be developed for clinical use as an alternative to transabdominal aminocentesis in the 16th week.

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Authors and Affiliations

  1. I.C.M.R. Genetic Research Centre, Bai Jerbai Wadia Hospital, Acharya Dhonde Marg, Parel, 400012, Bombay

    Z. M. Patel (Officer-in-Charge), V. R. Mulye, M. C. Mhatre, R. H. Suchak & V. B. Pathak

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  1. Z. M. Patel
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  2. V. R. Mulye
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  3. M. C. Mhatre
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  4. R. H. Suchak
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  5. V. B. Pathak
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Patel, Z.M., Mulye, V.R., Mhatre, M.C. et al. Chorionic villus sampling for first-trimester fetal diagnosis: preliminary experience. Indian J Pediatr 54, 685–688 (1987). https://doi.org/10.1007/BF02751279

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  • DOI: https://doi.org/10.1007/BF02751279

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