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The Indian Journal of Pediatrics

, Volume 54, Issue 1, pp 69–77 | Cite as

Diagnosis of intrathoracic tuberculosis by detection of tubercle bacilli and/or tubercular antigen (TB Ag) in bronchial aspirate

  • P. M. Udani
  • A. Samuel
  • G. V. Kadiwal
  • Vrajesh Udani
  • Soonu Patel
  • Alka Datar
  • S. A. Khatib
  • D. S. Sexena
Festschrift in Honour of Professor Harish Chandra, M.D., F.R.C.P.

Abstract

Bronchial aspirates in 160 children were examined for tubercle bacilli and were positive in 55 (34·4%). Tubercular antigen was detected in 56 of 79 children (70·9%). In 60 children in whom AFB or TB antigen was positive in bronchial washing antigen was positive in more than 96·7% of cases, indicating high sensitivity of antigen test. Moreover, antigen is specific for human and bovine mycobacteria. Only 15% of children who had tuberculosis proved by +ve antigen or +ve smear presented with usual characteristic symptoms of tuberculosis. About 75% of the children presented with recurrent or persistent bronchitis or pertussoid syndrome, while in 9% of children there were no significant symptoms. Mediastinal lymphnode involvement is common in children and 80% of AFB/antigen positive cases had only mediastinal lymphnode disease, while 20 also had parenchymal lesions. For the diagnosis of tuberculosis a simple technique such as examination of throat secretions for detection of TB antigen by RIA technique or ELISA has great potential.

Key words

Tuberculosis Extent of problem Bronchial aspirates Tubercular antigen by RIA 

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Copyright information

© Dr. K C Chaudhuri Foundation 1987

Authors and Affiliations

  • P. M. Udani
    • 1
  • A. Samuel
    • 1
  • G. V. Kadiwal
    • 1
  • Vrajesh Udani
    • 1
  • Soonu Patel
    • 1
  • Alka Datar
    • 1
  • S. A. Khatib
    • 1
  • D. S. Sexena
    • 1
  1. 1.Medical Research Centre, Bombay Hospital and Radiation Medical CentreBARCBombay

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