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Septic shock: Pathogenesis and treatment

  • Symposium: Pediatric intensive Care—II
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Abstract

Septic shock is the host’s inflammatory response to infection. There are multiple endogenous mediators responsible for the pathogenesis of septic shock. Cytokines, nitric oxide and prostaglandins are some of the major mediators. The term sepsis syndrome allows for an earlier diagnosis and treatment. Management of septic shock is focused in maintaining hemodynamic stability and an adequate oxygen delivery and utilization. Careful attention to each organ-system is of paramount importance to prevent complications and improve outcome. Experimental therapies to modulate the inflammatory response are promising.

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Author notes

  1. Leticia Castillo

    Present address: Pediatric and neonatal Intensive Care Unit, Department of Pediatrics, Harvard Medical School, Massachusetts General Hospital, Ellison 317, 02114, Boston, MA, U.S.A.

Authors and Affiliations

  1. Pediatric and neonatal Intensive Care Unit, Children's Service, Massachusetts General Hospital, Ellison 317, 02114, Boston, MA, U.S.A.

    Leticia Castillo & Melchor Sanchez

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  1. Leticia Castillo
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  2. Melchor Sanchez
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Castillo, L., Sanchez, M. Septic shock: Pathogenesis and treatment. Indian J Pediatr 60, 367–379 (1993). https://doi.org/10.1007/BF02751198

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