Abstract
The frequency of congenital malformations in a retrospective study done on 10,000 consecutive births from January 1983 to March 1989 was 3.6%. The predominant system involved was CNS. Major malformations constituted 79.7% of the total. Malformations were seen 4 times more often among still births. The common malformations in still births were also of CNS. The frequency of malformations was similar in both the sexes, though genitourinary anomalies were commoner among male, while anencephaly in female babies. A statistically significant increase in the frequency of congenital malformations was observed with decreasing gestation and birth weight. There was a significant correlation between maternal factors, like previous abortions, drug intake and fever during 1st trimester, diabetes mellitus, pre-eclamptic toxemia, antepartum hemorrhage and congenital malformations in the baby.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Kulkarni ML. Congenital malformations—editorial.Indian Pediatr 1989; 26: 5–10.
David TJ. Pathogenesis of congenital malformations. In: Boyd R, Battaglia FC. Eds.Perinatal Medicine. London: Butterworths, 1983; 264–285.
Homes LB. Congenital malformations. In: Vaughan VC, Behrman RE. Eds.Nelson's Text Book of Pediatrics. Tokyo: Igaku-Shoin Saunders, 1983; 311–312.
Nair MKC.Congenital Anomalies in Hospital Born Babies (Live and Still Births). Thesis for MD Pediatrics 1981, Punjab University.
Ghosh S, Bali L. Congenital malformations in newborn.Indian J Child Health 1963; 12: 448–450.
Saifullah S, Chandra RK, Pathak IC, Dhall GI. Congenital malformations in newborn.Indian Pediatr 1967; 4: 251–261.
Tibrewala NS, Pai PM. Congenital malformations in newborn period.Indian Pediatr 1974; 11: 403–407.
Mishra PC, Baveja R. Congenital malformations in the newborn—A prospective study.Indian Pediatr 1989; 26: 32–35.
Hemrajani KH et al. Congenital malformations in newborn.Pediatr Clin India 1971; 6: 51–54.
Stevenson AC, Johnston HA, Golding DR, Stewart MIP. Congenital malformations: A report of study of series of consecutive births in 24 centres.Bull WHO 1966; Suppl to Vol. 34: 9.
Terry PM, Bissenden JG, Candie RG, Mathew PM. Ethnic differences in congenital malformations.Arch Dis Child 1985; 60: 866–879.
Goravalingappa JP, Nashi HK. Congenital malformations in a study of 2398 consecutive births.Indian J Med Res 1979; 69: 140–146.
Kulshreshtha R, Nath LM, Upadhyaya P. Congenital malformations in liveborn infants in a rural community.Indian Pediatr 1983; 20: 45–49.
Mathur BC, Karan S, Vijayadevi KK. Congenital malformations in newborn.Indian Pediatr 1975; 12: 179–183.
Thirumalaikolundusubramanian P, Jayaprakash CA. Congenital anomalies and sex of the baby.Indian Pediatr 1985; 22: 75.
Guha A, Mukherjee DP. Trends of congenital malformations in two Calcuta hospitals with special reference to anencephaly.J Indian Anthrop Soc 1980; 15: 157–166.
Chaudhry A, Talukder G, Sharma A. Neonatal congenital malformations in Calcutta.Indian Pediatr 1984; 21: 399–405.
Cohen EN et al. Occupational disease among operating room personnel—A national study.Anesthesiology 1974; 4: 321–340.
Corbett TH, Cornell RG, Endres JL, Lieding K. Birth defects among children of Nurse-anesthetists.Anesthesiology 1974; 4: 341–344.
Chopra J, Rao HN, Indira C et al. Role of congenital anomalies in perinatal mortality.J Obstet Gynecol India 1982; 33: 27–30.
Singh M. Hospital based data on perinatal and neonatal mortality in India.Indian Pediatr 1986; 23: 579–584.
Smithells RW, Nevin NC, Sellar MJ et al. Further experience of vitamin supplementation for prevention of neural tube defects recurrences.Lancet 1983; 1: 1027–1031.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Verma, M., Chhatwal, J. & Singh, D. Congenital malformations—A retrospective study of 10,000 cases. Indian J Pediatr 58, 245–252 (1991). https://doi.org/10.1007/BF02751129
Issue Date:
DOI: https://doi.org/10.1007/BF02751129