Abstract
A form of unexplained arthritis, not attributable to known causes, seen in children (0–14 yrs) in this endemic zone of Bancroftian filariasis was investigated for its association with filariasis. Nineteen cases of undiagnosed arthritis were screened for filarial IgG antibodies to Wuchereria by Stick Enzyme Linked Immunosorbent Assay (ELISA). All had large joint involvement, the commonest joint affected being the knee joint. Involvement was monoarticular in 10 and binarticular in 9. Joint pain was present in 18 and effusion in 12. Five patients had recurrent episodes. Sixteen (84.2%) showed filarial antibodies of which only one (5.3%) was microfilaraemic. Patients with classical filariasis (16), disease controls (10), endemic normals (15) and non-endemic normals (10) were also subjected to ELISA to ascertain the sensitivity and specificity of the technique. Fifteen (93.8%) cases of classical filariasis and 1 (6.7%) of endemic normal were antibody positive, whereas none of disease controls and non-endemic normals had filarial antibodies. Nine cases of filarial arthritis reviewed after a course of Diethylcarbamazine showed satisfactory response to treatment.
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References
Joe LK. Occult filariasis; Its relationship with tropical pulmonary eosinophilia.Hygie 1962; 11: 646–652.
Beaver PG. Filariasis without microfilaraemia.Am J Trop Med Hyg 1970; 19: 181–189.
Partono F. The spectrum of lymphatic filariasis. InFilariasis, Ciba Foundation Symposium 127. New York: A Wiley-Interscience Publication 1987: 15–31.
Ismail MM. Occult filariasis. Tropical pulmonary eosinophilia and other obscure syndromes associated with lymphatic filarial parasites.WHO Report 1983; FII/BC/WP/83.8.
Ismail MM, Nagaratnam N. Arthritis possible due to filariasis.Trans R Soc Trop Med Hyg 1973; 67: 405–409.
Chugh KS, Singal PC, Tewari SC et al. Acute glomerulonephritis associated with filariasis.Am J Trop Med Hyg 1978; 27: 630–631.
WHO. Lymphatic filariasis. Fourth report of the WHO expert committee on Filariasis, Geneva.WHO Tech Rep Series 1984; 702.
Rao CK, Kumar S. Role of filariasis in endomyocardial fibrosis.J Comm Dis 1982; 14: 91–95.
Napier LE. The Principles and practice of Tropical Medicine. New York: McMillan, 1946: 675–677.
Manson Bahr PEC, Bell DR.Manson's Tropical Diseases, 19th ed. London: Baillere Tindal, 1987: 362–363.
Das GC, Sen SB. Chylous arthritis.Br Med J 1968; 2: 27–29.
Parkhe KA, Prasad GBKS, Das A et al. Disc/Stick ELISA for diagnosis of Bancroftian filariasis.Indian J Exp Biol 1986; 24: 437–439.
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Chaturvedi, P., Gawdi, A.M., Parkhe, K. et al. Arthritis in children: An occult manifestation of Bancroftian filariasis. Indian J Pediatr 60, 803–807 (1993). https://doi.org/10.1007/BF02751052
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DOI: https://doi.org/10.1007/BF02751052