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Latex agglutination test: An adjunct to the laboratory diagnosis of pyogenic bacterial meningitis

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Abstract

Gram stain, culture and latex agglutination test (LAT) of cerebrospinal flud were performed in 50 patients clinically diagnosed as suffering from pyogenic bacterial meningitus. Using all the three techniques, an aetiological diagnosis was made in 27 (54%).Neisseria meningitidis, Streptococcus pneumoniae and H. influenzae were the infecting organisms in 21 cases (44%). There were 12 additional cases in which LAT was the only clue to the diagnosis as compared to conventional techniques.Propionibacterium acnes was isolated from one case of anaerobic meningitis. It is concluded that LAT is an adjunct to conventional techniques in the diagnosis of pyogenic bacterial meningitis, where the latter tests fail.

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References

  1. Baired DR, Whitle HC, Greenwood BM. Mortality from pneumococcal meningitis.Lancet 1975; 21: 1344–1346.

    Google Scholar 

  2. Bohr V, Paulson O, Rassmussen N. Pneumococcal meningitis: Late neurologic sequelae and features of Prognostic impact.Arch Neurol 1984; 41: 1045–1049.

    Article  CAS  PubMed  Google Scholar 

  3. Sutter VL, Citron DM, Edelstein MAC, Finegold SM.Wadsworth Anaerobic Bacteriology Manual. Belmont, California: Start Publishing, 1985: 23–73.

    Google Scholar 

  4. Bhatia SL, Sharma KB, Natarajan R: An outbreak of meningococcal meningitis in Delhi.Indian J Med Res 1968; 56: 259–263.

    CAS  PubMed  Google Scholar 

  5. Reddi JP. Pyogenic meningitis in infants and children.Indian Pediatr 1973; 10: 413–417.

    CAS  PubMed  Google Scholar 

  6. Monteflore D, Alausa OK, Sobaya E. Pyogenic meningitis in Ibadan, Nigeria: A 15 month prospective study.Scand J Infect Dis 1978; 10: 113–117.

    Article  Google Scholar 

  7. Chattopadhyay B.Bacteriodes fragilis meningitis.Lancet 1977; i: 1371–1372.

    Article  Google Scholar 

  8. Odugbeni TO, Jatto SA, Afolabt K.Bacteroides fragilis meningitis.J Clin Microb 1985; 21: 282–283.

    Google Scholar 

  9. Willis AT.Anaerobic Bacteriology: Clinical and Laboratory Practice. 3rd ed. London: Butterworths, 1977: 198–200.

    Google Scholar 

  10. Richards J, Ingham HR, Hickmar J et al. Focal infections of the central nervous system due toPropionibacterium acnes.J Infect 1989; 18: 279–282.

    Article  CAS  PubMed  Google Scholar 

  11. Brook I. Anaerobic bacterial bacter-aemia: 12 years experience in two military hospitals.J Infect Dis 1989; 160: 1071–1075.

    Article  CAS  PubMed  Google Scholar 

  12. Whittle HE, Esler LJ, Tugwell P, Greenwood BM. Rapid bacteriological diagnosis of pyogenic meningitis.Lancet 1974; ii: 619–621.

    Article  Google Scholar 

  13. Dirks-GO SIS, Zanen HC. Latex agglutination, CIE and protein coagglutination in diagnosis of bacterial meningitis.J Clin Path 1978; 31: 1167–1170.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Kaldor J, Asznowicz R, Burst DCP. Latex agglutination in diagnosis of bacterial infections with special reference to patients with meningitis and septicaemia.Am J Clin Path 1977; 68: 284–287.

    Article  CAS  PubMed  Google Scholar 

  15. Bhujwala RA. Rapid diagnosis of meningitis.Indian Pediatr 1988; 25: 315–317.

    CAS  PubMed  Google Scholar 

  16. Singh H, Sarkar R, Sachdeva HPS, Saini L. Immunological tests in acute bacterial meningitis.Indian Pediatr 1988; 25: 323–328.

    CAS  PubMed  Google Scholar 

  17. Kaplan SL, Feign RD. Rapid identification of invading microorganism.Pediatr Clin North Am 1980; 27: 790–794.

    Article  Google Scholar 

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Mirdha, B.R., Gupta, U. & Bhujwala, R.A. Latex agglutination test: An adjunct to the laboratory diagnosis of pyogenic bacterial meningitis. Indian J Pediatr 58, 521–524 (1991). https://doi.org/10.1007/BF02750934

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