Abstract
Fifteen low birth weight premature infants with a diagnosis of PDA were administered 0·2 mg/kg of indomethacin orally, 3 doses at 12 hourly intervals. The results were compared with 18 prematures who were managed by fluid restriction (80–100 ml/kg/day) and decongestive therapy. Nine out of the 15 cases who received indomethacin met with the criteria of response, compared with only 2 out of 18 in whom there was spontaneous closure (P<0·01). Eleven of 15 cases who received indomethacin survived compared to only 6 of 18 in the control group (P<0·01). Overall mortality due to PDA alone was 58·9 per cent. Indomethacin when administered orally and sufficiently early, is safe and effective in closing PDA in premature infants. This modality of treatment is feasible in the Indian set up.
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References
Nadas AS. Editorial comment—indomethacin and patent ductus arteriosus.N Engl J Med 1981;305: 97
Brash AR, Hickey DE, Graham TP et al. Pharmakokinetics of indomethacin in the neonate.N Engl J Med 1981;305: 67–70
Alpert BS, Lewins MJ, Rowland DW et al. Plasma indomethacin levels in preterm newborns with symptomatic patent ductus arteriosus, clinical and echocardiographic assessments of response.J Pediatr 1979;95: 578–582
Bhat R, Vidyasagar D, Vadapalli M et al. Disposition of indomethacin in premature infants.J Pediatr 1979;95: 313–316
Thalji AA, Carr I, Yeh TF et al. Pharmacokinetics of intravenously administered indomethacin in premature infants.J Pediatr 1980;97: 995–1000
Martha DM, Thomas WC, David ZM et al. Indomethacin for closure of patent ductus arteriosus in prematures.Clin Pediatr 1982;21: 217–220
McCarthy JS, Lees LG, Gelband H. Age dependent closure of patent ductus arteriosus by indomethacin.Pediatrics 1978;62: 706–712
Friedman WF, Herschklan MJ, Printz MPet al. Pharmacological closure of patent ductus arteriosus in the premature infant.N Engl J Med 1976;95: 526–529
Halliday HL, Hirata T, Brady JP. Indomethacin therapy for large patent ductus arteriosus in low birth weight infant: Results and complications.Pediatrics 1979;64: 154–159
Bhat R, Fisher E, TNK Raju and Vidyasagar D. Recent advances in diagnosis and management of PDA.Ped Clin North Amer 1982;29: 5, 1117–1136
Ivey HH, Kattwinkel J, Park TS et al. Failure of indomethacin to close persistent ductus arteriosus in infants weighing under 1000 gm.Br Heart J 1979;41: 304–307
Cooke RWI, Pickering D. Poor response to oral indomethacin to close patent ductus arteriosus in very low birth weight infants.Br Heart J 1979;41: 301–304
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Nair, P.A.K., Karan, S. Indomethacin for closure of patent ductus arteriosous in preterm neonates. Indian J Pediatr 53, 499–503 (1986). https://doi.org/10.1007/BF02749534
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DOI: https://doi.org/10.1007/BF02749534