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Preoperative chemotherapy for cStage III-pN0 patients with non-small cell lung cancer

The Japanese Journal of Thoracic and Cardiovascular Surgery volume 54, pages 109–113 (2006)Cite this article

Abstract

Objectives: Survival benefits with preoperative chemotherapy for non-small cell lung cancer (NSCLC) remain controversial. Preoperative chemotherapy may act on micrometastasis but not lymph node metastasis. To clarify the role of induction chemotherapy for control of micrometastasis, we reviewed and compared 5-year follow-ups of clinical stage III but pathologically-proven node-negative NSCLC patients after complete resection with or without preoperative chemotherapy. Methods: We reviewed 148 consecutive patients who underwent anatomical lung resection and mediastinal nodal dissection for pathologically-proven node-negative NSCLC at our hospital between 1994 and 1999. Fifty-six patients were preoperatively diagnosed as stage III: 26 received platinum-based chemotherapy prior to surgery (PCT group) and 30 underwent surgery without any prior chemotherapy (PRS group). Results: The 5-year survival rate for clinical stage I/II and pathological node-negative patients was 74.9%; for clinical stage III, but for pathological node-negative patients it was 92.3% in the PCT and 63.3% in the PRS groups. The survival benefit of preoperative chemotherapy was significant for clinical stage III patients without node involvement. Conclusion: Preoperative chemotherapy may provide survival benefits for node-negative NSCLC patients.

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Affiliations

  1. Division of General Thoracic Surgery, Department of Surgery, Jichi Medical School, Minamikawachi, Kawachi-gun, 329-0498, Tochigi, Japan

    Shunsuke Endo MD, Hiroyoshi Tsubochi MD, Kenji Tetsuka MD, Yukio Sato MD, Tsuyoshi Hasegawa MD, Shinichi Otani MD, Noriko Saito MD & Yasunori Sohara MD

Authors
  1. Shunsuke Endo MD
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  2. Hiroyoshi Tsubochi MD
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  3. Kenji Tetsuka MD
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  4. Yukio Sato MD
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  5. Tsuyoshi Hasegawa MD
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  6. Shinichi Otani MD
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  7. Noriko Saito MD
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  8. Yasunori Sohara MD
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Endo, S., Tsubochi, H., Tetsuka, K. et al. Preoperative chemotherapy for cStage III-pN0 patients with non-small cell lung cancer. Jpn J Thorac Caridovasc Surg 54, 109–113 (2006). https://doi.org/10.1007/BF02744872

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  • DOI: https://doi.org/10.1007/BF02744872

Key words

  • non-small cell lung cancer
  • early stage lung cancer
  • preoperative chemotherapy
  • survival benefit