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  • Proceedings of the Satellite of the 14th ISN Meeting and the First International Workshop entitled The Neuronal Phenotype Molecular Biology, Cell Specification, and Therapeutic Frontiers held in Lozari, Corsica, France, August 19–20, 1993
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Brief overview of control of genetic expression by antisense oligonucleotides and in vivo applications

Prospects for neurobiology

Molecular Neurobiology volume 10, pages 219–229 (1995)Cite this article

Abstract

Over the past several years, the use of synthetic oligonucleotides and functional analogs thereof as a possibly general means of controlling genetic expression has received widespread attention. Following a brief overview of some of the basic principles and strategies for this approach, attention is focused here on summarizing some recent reports of in vitro and, in particular, in vivo investigations in various animal models using phosphorothioate analogs of 2′-deoxyoligo-nucleotides. In view of these findings, which include studies related to neurobiology, this field should find significant utility in applications of the antisense method for controlling genetic expression.

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  1. Lynx Therapeutics, Inc., 3832 Bay Center Place, 94545, Hayward, CA

    Gerald Zon

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Zon, G. Brief overview of control of genetic expression by antisense oligonucleotides and in vivo applications. Mol Neurobiol 10, 219–229 (1995). https://doi.org/10.1007/BF02740677

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Index Entries

  • Genetic expression
  • antisense
  • oligonucleotides
  • phosphorothioate analogs
  • in vitro activity
  • animal models
  • neurobiology