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The role of glycoproteins in neural development, function, and disease

Molecular Neurobiology volume 16, pages 163–220 (1998)Cite this article

Abstract

Glycoproteins play key roles in the development, structuring, and subsequent functioning of the nervous system. However, the complex glycosylation process is a critical component in the biosynthesis of CNS glycoproteins that may be susceptible to the actions of toxicological agents or may be altered by genetic defects. This review will provide an outline of the complexity of this glycosylation process and of some of the key neural glycoproteins that play particular roles in neural development and in synaptic plasticity, in the mature CNS. Finally, the potential of glycoproteins as targets for CNS disorders will be discussed.

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Author notes

  1. Christine M. Coughlan

    Present address: Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical School, Philadelphia, PA

  2. Fleur D. Hayes

    Present address: School of Biomedical Sciences, University of St. Andrews, Scotland, UK

Affiliations

  1. Neurosciences Institute, Department of Pharmacology and Clinical Pharmacology, University of Dundee, Ninewells Hospital Medical School, DD1 9SY, Dundee, Scotland, UK

    Kieran C. Breen, Christine M. Coughlan & Fleur D. Hayes

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  1. Kieran C. Breen
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  2. Christine M. Coughlan
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  3. Fleur D. Hayes
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Breen, K.C., Coughlan, C.M. & Hayes, F.D. The role of glycoproteins in neural development, function, and disease. Mol Neurobiol 16, 163–220 (1998). https://doi.org/10.1007/BF02740643

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Index Entries

  • Glycoproteins
  • cell-adhesion molecules
  • teratogenic neurotoxins