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Recurrence in parathyroid hyperplasias owing to secondary hyperparathyroidism is predicted by morphological patterns and proliferative activity values

Endocrine Pathology volume 7, pages 55–61 (1996)Cite this article

Abstract

The histological pattern and the cell proliferative activity (as detected by Ki-67 immunostaining) of a series of 50 parathyroid hyperplasias (PTHs) secondary to renal failure were studied to assess their value in predicting recurrence of hyperparathyroidism (HPT). On account of their clinical evolution, these cases were divided into two groups: recurrent HPT (23 cases) and nonrecurrent HPT (27 cases). A nodular growth pattern (as opposed to diffuse) was the prevalent one and was observed in 20 (74%) cases of nonrecurrent HPT and in 22 (95.6%) cases of recurrent HPT, a statistically significant difference (p<0.05). The Ki-67 proliferative fraction was 1.9% in recurrent HPT cases, as compared with 0.81% in nonrecurrent HPT, a difference which was statistically significant (p=0.001). We conclude that a nodular pattern of growth and an elevated Ki-67 proliferative fraction (>1.5%) in PTH are both associated with a higher risk of recurrence (4.30) of HPT.

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Affiliations

  1. Department of Biomedical Sciences and Oncology, University of Turin, Via Santena 7, I-10126, Torino, Italy

    GianCarlo Abbona MD, Mauro Papotti MD & Gianni Bussolati MD, FRCPath

  2. Department of Surgery, University of Turin, Via Santena 7, I-10126, Torino, Italy

    Guido Gasparri MD

Authors
  1. GianCarlo Abbona MD
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  2. Mauro Papotti MD
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  3. Guido Gasparri MD
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  4. Gianni Bussolati MD, FRCPath
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Abbona, G., Papotti, M., Gasparri, G. et al. Recurrence in parathyroid hyperplasias owing to secondary hyperparathyroidism is predicted by morphological patterns and proliferative activity values. Endocr Pathol 7, 55–61 (1996). https://doi.org/10.1007/BF02739915

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  • DOI: https://doi.org/10.1007/BF02739915

Key Words

  • Parathyroid hyperplasia (PTH)
  • hyperparathyroidism (HPT)
  • proliferative activity
  • Ki-67