Endocrine Pathology

, Volume 8, Issue 1, pp 75–80 | Cite as

Epithelial cyst of thyroid

  • Catherine J. StreutkerEmail author
  • David Murray
  • Kalman Kovacs
  • Hubert P. Higgins
Case Report


A benign thyroid cyst lined by thyroid follicular epithelial cells lacking immunoreactivity to thyroglobulin is reported. The patient had a 3 yr history of a large cyst in the lateral anterior neck, with no symptoms of hyperthyroidism or hyperparathyroidism. Water-clear fluid was repeatedly aspirated; analysis indicated the absence of parathyroid hormone (PTH), T3, and T4. Hemithyroidectomy revealed a simple epithelial cyst. Such cysts are rare, comprising approx 1% of thyroid nodules. A differential diagnosis of cystic neck lesions is presented and the possible pathogenesis of this cyst is discussed.

Key Words

Epithelial cyst thyroid pathology 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Cusick EL, McIntosh CA, Krukowski ZH, Matheson NA. Cystic change and neoplasia in isolated thyroid swellings. Br J Surg 75:982,983, 1988.PubMedCrossRefGoogle Scholar
  2. 2.
    Hammer M, Wortsman J, Folse R. Cancer in cystic lesions of the thyroid. Arch Surg 117:1020–1023, 1982.PubMedGoogle Scholar
  3. 3.
    Crile G Jr, Hawk WA Jr. Aspiration biopsy of thyroid nodules. Surg Gynecol Obstet 136:241–245, 1973.PubMedGoogle Scholar
  4. 4.
    Crile G Jr. Treament of thyroid cysts by aspiration. Surgery 59:210–212, 1966.PubMedGoogle Scholar
  5. 5.
    Rosen IB, Provias JP, Walfish PG. Pathologic nature of cystic thyroid nodules selected for surgery by needle aspiration biopsy. Surgery 100:606–612, 1986.PubMedGoogle Scholar
  6. 6.
    Miskin M, Rosen IB, Walfish PG. B-Mode ultrasonography in assessment of thyroid gland lesions. Ann Int Med 79:505–510, 1973.PubMedGoogle Scholar
  7. 7.
    de los Santos ET, Keyhani-Rofagha S, Cunningham JJ, Mazzaferri EL. Cystic thyroid nodules; the dilemma of malignant lesions. Arch Intern Med 150:1422–1427, 1990.PubMedCrossRefGoogle Scholar
  8. 8.
    Simeone JF, Daniels GH, Mueller PR, Maloof F, van Sonnenberg E, Hall DA, O'Connell RS, Ferrucci RS Jr, Wittenberg J. High resolution real-time sonography of the thyroid. Radiology 145:431–435, 1982.PubMedGoogle Scholar
  9. 9.
    McHenry CR, Walfish PG, Rosen IB Non-diagnostic fine needle aspiration biopsy: a dilemma in management of nondular thyroid disease. Am Surgeon 59:415–419, 1993.PubMedGoogle Scholar
  10. 10.
    Jennings AS. Nonisotopic techniques of thyroid imaging. In: Braverman LE, Utiger RD, eds. Werner and Ingbar's The thyroid, a fundamental and clinical text. 6th ed. New York, NY, J. B. Lippincott, 1996; 525–543.Google Scholar
  11. 11.
    Blum M. Ultrasonography and computed tomography of the thyroid gland. In: Ingbar SH, Braverman LE, eds. Werner's The thyroid, a fundamental and clinical text. 5th ed. New York, NY, J. B. Lippincott, 1986; 576–591.Google Scholar
  12. 12.
    Kovacs K, Stefaneanu L, Horvath E, Lloyd RV, Lancranjan I, Buchfelder M, Fahlbusch R. Effect of dopamine agonist medication on prolactin producing pituitary adenomas. Virchows Arch A Pathol Anat 418:39–46, 1991.CrossRefGoogle Scholar
  13. 13.
    Clark OH, Okerlund MD, Cavalieri RR, Greenspan FS. Diagnosis and treatment of thyroid, parathyroid and thyroglossal duct cysts. J Clin Endo Metab 48:983–988, 1979.CrossRefGoogle Scholar
  14. 14.
    Rehak NN, Oertel YC, Herp A, Chiang BT, Csako G. Biochemical analysis of thyroid cyst fluid obtained by fine-needle aspiration. Arch Pathol Lab Med 117:625–630, 1993.PubMedGoogle Scholar
  15. 15.
    Miller JM, uz Zafar S, Karo JJ. The cystic thyroid nodule: recognition and management. Radiology 110:257–261, 1974.PubMedGoogle Scholar
  16. 16.
    Ginsberg J, Young JEM, Walfish PG. Parathyroid cysts; medical diagnosis and management. JAMA 240:1506,1507, 1978.PubMedCrossRefGoogle Scholar
  17. 17.
    Crile GJ Jr, Perryman RG. Parathyroid cysts; a report of five cases. Surgery 34:151–154, 1953.PubMedGoogle Scholar
  18. 18.
    Katz AD, Dunkleman D. Needle aspiration of nonfunctioning parathyroid cysts. Arch Surg 119:307,308, 1984.PubMedGoogle Scholar
  19. 19.
    Alvi A, Myssiorek D, Wasserman P. Parathyroid cyst: current diagnostic and management principles. Head Neck 18:370–373, 1996.PubMedCrossRefGoogle Scholar
  20. 20.
    Som PM, Sacher M, Lanzieri CF, Solodnik P, Cohen BA, Reede DL, Bergeron ST, Biller HF. Parenchymal cysts of the lower neck. Radiology 157:399–406, 1985.PubMedGoogle Scholar
  21. 21.
    Shareef DS, Salm R. Ectopic vestigial lesions of the neck and shoulders. J Clin Pathol 34:1155–1162, 1981.PubMedCrossRefGoogle Scholar
  22. 22.
    Harnsberger HR, Mancuso M, Muraki AS, Byrd SE, Dillon WP, Johnson LP, Hanafee WN. Branchial cleft anomalies and their mimics: computed tomographic evaluation. Radiology 152:739–748, 1984.PubMedGoogle Scholar
  23. 23.
    Simons JN, Robinson DW, Masters FW. Cervical thymic cyst. Am J Surg 108:578–582, 1964.PubMedCrossRefGoogle Scholar
  24. 24.
    Mikal S. Cervical thymic cyst; case report and review of the literature: Arch Surg 109:558–562, 1974.PubMedGoogle Scholar
  25. 25.
    Silverman PM, Korobkin M, Moore AV. Case report; CT diagnosis of cystic hygroma of the neck. J Comput Assist Tomogr 7:519–520, 1983.PubMedGoogle Scholar
  26. 26.
    Som PM, Zimmerman RA, Biller HF. Cystic hygroma and facial nerve paralysis: a rare association. J Comput Assist Tomogr 8:110–113, 1984.PubMedGoogle Scholar
  27. 27.
    Tovi F, Zirkin H. Solitary lateral cervical cyst: presenting symptom of papillary thyroid adenocarcinoma. Ann Otol Rhinol Laryngol 92:521–524, 1983.PubMedGoogle Scholar
  28. 28.
    Cinberg JZ, Silver CE, Molnar JJ, Vogl SE. Cervical cysts: cancer unitil proven otherwise? Laryngoscope 92:27–30, 1982.PubMedCrossRefGoogle Scholar
  29. 29.
    Katz, AD. Midline dermoid tumors of the neck. Arch Surg 109:822,823, 1974.PubMedGoogle Scholar
  30. 30.
    Holt GR, Holt JE, Weaver RG. Dermoids and teratomas of the head and neck. Ear, Nose, Throat J 58:520–531, 1979.Google Scholar
  31. 31.
    Kumar AJ, Kuhajda FP, Martinez CR, Fishman EK, Jezic DV, Siegelman SS. Computed tomography of extracranial nerve sheath tumors with pathological correlation. J Comput Assist, Tomogr 7:857–865, 1983.Google Scholar
  32. 32.
    Apel RL, Asa SL, Chalvardjian A, LiVolsi VA. Intrathyroidal lymphoepithelial cysts of probable branchial origin. Hum Pathol 25:1238–1242, 1994.PubMedCrossRefGoogle Scholar
  33. 33.
    Louis DN, Vickery AL, Rosai J, Wang CA. Multiple branchial cleft-like cysts in Hashimoto's thyroiditis. Am J Surg Pathol 13:45–49, 1989.PubMedGoogle Scholar
  34. 34.
    Delabie J, De Wolf-Peeters C, Cappell L, Van Damme V. Branchial cleftlike, cysts of the thyroid. Am J Surg Pathol 14:1165–1166, 1990.PubMedCrossRefGoogle Scholar
  35. 35.
    Roediger WE, Kalk F, Spitz L, Schmaman A. Congenital thyroid cyst of ultimobranchial gland origin. J Ped Surg 12:575,576, 1977.CrossRefGoogle Scholar

Copyright information

© Humana Press Inc 1997

Authors and Affiliations

  • Catherine J. Streutker
    • 2
    Email author
  • David Murray
    • 2
  • Kalman Kovacs
    • 2
  • Hubert P. Higgins
    • 1
  1. 1.Department of MedicineMichael’s HospitalTorontoCanada
  2. 2.Department of PathologySt. Michael’s HospitalTorontoCanada

Personalised recommendations