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Relevance of somatostatin receptors and other peptide receptors in pathology

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Abstract

Receptors for regulatory peptides can be overexpressed by several diseases, in particular by neoplasms. This review summarizes the current status of knowledge in this field, on the basis of in vitro receptor studies and with emphasis on receptors for somatostatin as well as for substance P (SP), vasoactive intestinal polypeptide (VIP), and cholecystokinin. It evaluates the existing and potential clinical implications of the findings for diagnosis and therapy and discusses the role of the pathologist in this context.

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Authors and Affiliations

  1. Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Berne, Murtenstrasse 31, CH-3010, BERNE, (Switzerland)

    Jean Claude Reubi MD (Professor of Pathology)

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  1. Jean Claude Reubi MD
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Reubi, J.C. Relevance of somatostatin receptors and other peptide receptors in pathology. Endocr Pathol 8, 11–20 (1997). https://doi.org/10.1007/BF02739703

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