Abstract
This study investigated what effect a 30% oxygen administration had on visuospatial cognitive performance and cerebral activation and lateralization using fMRI. Eight college students were selected as the subjects for this study. An oxygen dispenser that provided 21% and 30% oxygen at a constant rate of 8L/min was developed. In order to measure the performance level of visuospatial cognition, two psychological tests were also developed. The experiment consisted of two runs, one for a visuospatial cognition task with normal air (21% oxygen) and the other for a visuospatial cognition task with hyperoxic air (30% oxygen). Functional brain images were taken with a 3T MRI using the single-shot EPI method. The results of the visuospatial behavioral analysis reveal that accuracy rates were enhanced with 30% oxygen administration when compared to 21% oxygen. There were more activations observed at the bilateral occipital, parietal, and frontal lobes with 30% oxygen administration. However, decreased cerebrum lateralization was observed with 30% oxygen administration in the same regions compared with 21% oxygen administration. Thus, it is concluded that the positive effect on the visuospatial cognitive performance level by the highly concentrated oxygen administration resulted from an increase of cerebrum activation and a decrease of cerebrum lateralization.
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References
Andersson, J., Berggren, P., Gronkvist, M., Magnusson S., & Svensson, E. (2002). Oxygen saturation and cognitive performance.Psychopharmacology (Berlin) 162, 119–128.
Benton, D., Owens, D.S., & Parker, P.Y. (1994). Blood glucose influences memory and attention in young adults.Neuropsychologia 32, 595–607.
Carpenter, P.A., Just, M.A., Keller, T.A., Eddy, W., & Thulborn, K. (1999). Graded functional activation in the visuospatial system with the amount of task demand.Journal of Cognitive Neuroscience 11, 9–24.
Craft, S., Murphy, C., & Wernstrom, J. (1994). Glucose effects on complex memory and nonmemory tasks: The influence of age, sex, and glucoregulatory response.Psychobiology 22, 95–105.
Eustache, F., Rioux, P., Desgranges, B., Marchal, G., Petittaboue, M.C., Dary, M., Lechevalier, B., & Baron, J.C. (1995). Healthy aging, memory subsystems, and regional cerebral oxygen consumption.Neuropsychologia 33, 867–887.
Fink, G.R., Marshall, J.C., Weiss, P.H., & Zilles, K. (2001). The neural basis of vertical and horizontal line bisection judgments: an fMRI study of normal volunteers.Neuroimage 14, 59–67.
Friston, K., Holmes, A., Worsley, K., Poline, J., Frith, C., & Frackowiak, R. (1995). Statistical parametric maps in functional imaging: A general linear approach.Human Brain Mapping 2, 189–210.
Gold, P.E., Macleod, K.M., Deary, I.J., & Frier, B.M. (1985). Hypoglycaemic-induced cognitive dysfunction in diabetes mellitus: Effect of hypoglycaemic unawareness.Physiology & Behavior 58, 501–511.
Gur, R.C., Alsop, D., Glahn, D., Petty, R., Swanson, C.L., Maldjian, J.A., Turetsky, B.I., Detre, J.A., Gee, J., & Gur, R.E. (2000). An fMRI study of sex differences in regional activation to a verbal and a spatial task.Brain and Language 74, 157–170.
Horwitz, B., McIntosh, A.R., Haxby, J.V., & Grady, C.L. (1995). Network analysis of brain cognitive function using metabolic and blood-flow data.Behavioural Brain Research 66, 187–193.
Larson, G.E., Haier, R.J., Lacasse, L., & Hazen, K. (1995). Evaluation of a mental effort hypothesis for correlations between cortical metabolism and intelligence.Intelligence 21, 267–278. Lee, S.R. (1982).Intelligence test 151-Ga Type (High school students ≈ adults). Seoul, Korea: Jungangjucksung Press. Lee, S.R., & Kim, K.R. (1985).Aptitude test 251-Ga (High school students ≈ adults). Seoul, Korea: Jungangjucksung Press.
Moss, M.C., & Scholey, A.B. (1996). Oxygen administration enhances memory formation in healthy young adults.Psychopharmacology (Berlin) 124, 255–260.
Moss, M.C., Scholey, A.B., & Wesnes, K. (1998). Oxygen administration selectively enhances cognitive performance in healthy young adults: A placebo-controlled double blind crossover study.Psychopharmacology (Berlin) 138, 27–33.
Ng, V.W., Eslinger, P.J., Williams, S.C., Brammer, M.J., Bullmore, E.T., Andrew, C.M., Suckling, J., Morris, R.G., & Benton, A.L. (2000). Hemispheric preference in visuospatial processing: a complementary approach with fMRI and lesion studies.Human Brain Mapping 10, 80–86.
Ng, V.W., Bullmore, E.T., de Zubicaray, G.I., Cooper, A., Suckling, J., & Williams, S.C. (2001). Identifying rate-limiting nodes in large-scale cortical networks for visuospatial processing: An illustration using fMRI.Journal of Cognitive Neuroscience 13: 538–545. Noble, J., Jones, J.G., & Davis, E.J. (1993). Cognitive function during moderate hypoxaemia.Anaesthesia and Intensive Care 21: 180–184.
Ogawa, S., Tank, D.W., Menon, R., Ellermann, J.M., Kim, S.G., Merkle, H., & Ugurbil, K. (1992). Intrinsic signal changes accompanying sensory stimulation: Functional brain mapping with magnetic resonance imaging.Proceeding of the National Academy of Sciences of the United States of America 89, 5951–5955.
Park, S.B. (1985).GATB (General Aptitude Test Battery): Academic, job aptitude test type II (for students of middle schools, high schools and universities, and general public). Seoul, Korea: Jungangjucksung Press.
Scholey, A.B., Moss, M.C., & Wesnes, K.A. (1998). Oxygen and cognitive performance: The temporal relationship between hyperoxia and enhanced memory.Psychopharmacology (Berlin) 140: 123–126.
Scholey, A.B., Moss, M.C., Neave, N., & Wesnes, K. (1999). Cognitive performance, hyperoxia, and heart rate following oxygen administration in healthy young adults.Physiology & Behavior 67, 783–789.
Sohn, J.H., Kim, Y.H., Lee, K.H., Park, S.H., Lee, J.M., & Chung, S.C. (2002). An fMRI study to identify the brain structure for predicting the level of individual’s intelligence. Paper presented at the 8th International Conference on Functional Mapping of the Human Brain, Sendai, Japan.
Springer, S.P., & Deutsch, G. (1988).Left Brain, Right Brain. 5th ed. New York: W.H. Freeman.
Talairach, J., & Tournoux, P. (1988).Co-Planar Stereotaxic Atlas of the Human Brain. New York: Georg Thieme Verlag Stuttgart.
Vitouch, O., Bauer, H., Gittler, G., Leodolter, M., & Leodolter, U. (1997). Cortical activity of good and poor spatial test performances during and spatial and verbal processing studied with slow potential topography.International Journal of Psychology 27, 183–199.
Winder, R., & Borrill, J. (1998). Fuels for memory: The role of oxygen and glucose in memory enhancement.Psychopharmacology (Berlin) 136: 349–356.
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Chung, SC., Tack, GR., Kim, IH. et al. The effect of highly concentrated oxygen administration on cerebral activation levels and lateralization in visuospatial tasks. Integrative Physiological & Behavioral Science 39, 153–165 (2004). https://doi.org/10.1007/BF02734436
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DOI: https://doi.org/10.1007/BF02734436