Abstract
Objective : Interleukin-8 (IL-8) is produced in monocytes and vascular endothelial cells in response to stimulation with bacteria or lipopolysaccharides, and is released from these cells into blood stream or tissue fluid.Methods Cerebrospinal fluid (CSF) levels of interleukin-8 in 56 children with nonbacterial, bacterial and tuberculous meningitis (TBM), and in 15 control subjects were analyzed to evaluate the involvement of this cytokine in the pathogenesis acute bacterial meningitis and their discriminative value between different etiologies of meningitis. The kinetics of IL-8 concentrations during the course of bacterial meningitis was also evaluated in patients. IL-8 levels were significantly higher in bacterial and TBM than in aseptic meningitis and in control subjects (p<0.0001).Results: There was no difference in the levels of IL-8 between the non-bacterial meningitis and control groups. The analysis of the kinetics of production of IL-8 in patients with bacterial meningitis showed that the SSF concentrations of this cytokine decreased to undetectable values in recovery stage. Conversely in patients with TBM the concentrations of IL-8 were elevated in two weeks after beginning the specific treatment.Conclusion : The results suggest that determining IL-8 levels may be useful in the differential diagnosis.
Similar content being viewed by others
References
Quangliarello V, Scheid WM. Bacterial meningitis: pathogenesis, pathophysiology, and progress.N Engl J Med 1992; 327: 864–872.
Seki T, Joh K, Oh-ishi T. Augmented production of interleukin-8 in cerebrospinal fluid in bacterial meningitis.Immunology 1993; 80:333–35.
Ruscont F, Parizzzi F, Garlaschi Let al. Interleukin 6 activity in infants and children with bacterial meningitis.Pediatr Infect Dis J 1991; 10:117–121.
Torre D, Zeroli C, Ferraro Get al. Cerbrospinal fluid levels of IL-6 in patient withacute infections of the central nervous systems.Scand J Infect Dis 1992; 24: 787–791.
Ceyhan M, Kanra G, Ecevit Zet al. Tumor necrosis factor-a and interleukin-lb levels in children with bacterial, tuberculous and aseptic meningitis.Turk J Pediatr 1997; 39: 177–84.
Azuma H, Tsuda N, Sasaki K, Okuno A. Clinical significance of cytokines measurment for detection of meningitis.J Pediatr 1997; 131:463–165.
Luster AD. Chemokines-chemotactic cytokines that mediate inflammation.N Engl J Med 1998; 338: 436–445.
Peveri P, Walz A, Devald B, Baggliolini M. A noval neutrophil-activating factor produced by human mononuclear phagocytes.J Exp Med 1988; 167: 1547–1549.
Harada A, Sekido N, Akahashi T, Wada N, Mukaida N, Matsushima K. Essential involvement of interleukin-8 (IL-8) in acute inflammation.J Leukoc Biol 1994; 56: 559–564.
Ostergaard C, Yieng-kow RV, Benfield T, Frimodt-Moller N, Espersen F, Lundgren JD. Inhibition of leukocyte entry into the brain by the selection blocker fucoidin decreases interleukin-1 (IL-1) levels butincreases IL-8 levels in cerebrospinal fluid during experimental pneumococcal meningitis in rabbits.Infect Immun 2000; 68 (6): 3153–3157.
Lopez-Cortes LF, Cruz-Ruiz M, Gomez-Mateos J. Interleukin-8 in cerebrospinal fluid from patients with meningitis of different etiologies: its possible role as neutrophil chemotactic factor.J Infect Dis 1995; 172 : 581–584.
Van Deuren M, van der Ven-Jongekrijg B, Bertelinie AKM. Correlation between proinflammatory cytkines and antiinflammatory mediators and severity of disease in meningococcal infections.J Infect Dis 1995; 171: 433–439.
Halstensen A, Ceska M, Brandtzaeg P. Interleukin-8 in serum and cerebrospinal fluid from patients with meningococal disease.J Infect Dis 1993; 167: 471–75.
Van Meir E, Ceska M, Effenberger F. Interleukin-8 is produced in neoplastic and infectious diseases of the human central nervous systems.Cancer Res 1992; 52: 297–305.
Saez I, H MacCracken G. Meningitis. In. L Katz S, A Gershon A, J Hotez P, eds.Infectious Diseases of Children. St. Luis, Mosby, Inc., 1998; 265–279.
Baggiolini M, Walz A, Kunkel SL. Neutrophil-activating peptide 1/interleukin-8, a novel cytokines that activates neutrophils.J Clin Invest 1989; 84:1045–1049.
Detmers PA, Lo SK, Olsen-Egbert W, Walz A, Baggiolini M, Cohn ZA. Neutrophil-activating proteinl/interleukin 8 stimulates the binding activity of the leukocyte adhesion receptor CD11b/CD18 on human neutrophils.J Exp Med 1990; 171:1155–1162.
Mastroianni CM, Paoletti F, Rivosecchi RMet al. Cerebrospinal fluid intreleukin 8 in children with purulent bacterial and tuberculous meningitis.Pediatr Infect Dis J 1994; 13:1008–1010.
Ostergaard C, Benfield TL, Sellebjerg F, Kronborg G, Lohse N, Lundgren JD. Interleukin-8 in cerebrospinal fluid from patients with septic and aseptic meningitis.Eur J Clin Microbiol Infect Dis 1996; 15:166–169.
Yokoyama T, Oda M, Ogura S, Horiuchi T, Seino Y. Relationship of interleukin-8 and colony-stimulating factors to neutrophil migration in aseptic meningitis.Acta Paediatr 1996; 85: 303–307.
Ishiguro A, Suzuki Y, Inaba Yet al. The production of IL-8 in cerebrospinal fluid in aseptic meningitis of children.Clin Exp Immunol 1997;109:426–430.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Yilmaz, E., Gürgöze, M.K., Ilhan, N. et al. Interleukin-8 levels in children with bacterial, tuberculous and aseptic meningitis. Indian J Pediatr 69, 219–221 (2002). https://doi.org/10.1007/BF02734223
Issue Date:
DOI: https://doi.org/10.1007/BF02734223