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A comparison of latent inhibition and learned irrelevance pre-exposure effects in rabbit and human eyeblink conditioning

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Abstract

The learning of an association between a CS and a US can be retarded by unreinforced presentations of the CS alone (termed latent inhibition or LI) or by un-correlated presentations of the CS and US (termed learned irrelevance or LIRR). In rabbit eyeblink conditioning, there have been some recent failures to replicate LI. LIRR has been hypothesized as producing a stronger retardation effect than LI based on both empirical studies and computational models. In the work presented here, we examined the relative strength of LI and LIRR in eyeblink conditioning in rabbits and humans. In both species, a number of pre-exposure trials sufficient to produce LIRR failed to produce LI (Experiments 1 & 3). Doubling the number of CS pre-exposures did produce LI in rabbits (Experiment 2), but not in humans (Experiment 4). LI was demonstrated in humans only after manipulations including an increased inter-trial interval or ITI (Experiment 5). Overall, it appears that LIRR is a more easily producible pre-exposure retardation effect than LI for eyeblink conditioning in both rabbits and humans. Several theoretical mechanisms for LI including the conditioned attention theory, stimulus compression, novelty, and the switching theory are discussed as possible explanations for the differences between LIRR and LI. Overall, future work involving testing the neural substrates of pre-exposure effects may benefit from the use of LIRR rather than LI.

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References

  • Allen, M. T. & M. A. Gluck. (1997). Learned irrelevance pre-exposure inhibits acquisition of the classically conditioned rabbit eyeblink response.Society for Neuroscience Abstracts, 23.

  • Baker, A. (1976). Learned irrelevance and learned helplessness: Rats learn that stimuli, reinforcers and responses are uncorrelated.Journal of Experimental Psychology: Animal Behavior Processes, 2: 130–141.

    Article  Google Scholar 

  • Baker, A. & N. Mackintosh. (1979). Preexposure to the CS alone, US alone, or CS and US uncorrelated: Latent inhibition, blocking by context or learned irrelevance?Learning and Motivation, 10: 278–294.

    Article  Google Scholar 

  • Bennett, C., A. Maldonado & N. Mackintosh. (1995). Learned irrelevance is not the sum of exposure to CS and US.Quarterly Journal of Experimental Psychology, 48B: 117–128.

    Google Scholar 

  • Berry, S. D., M. A. Seager, Y. Asake & R. L. Borgnis. (2000). Motivational issues in aversive and appetitive conditioning paradigms. In D. S. Woodruff-Pak and J. E. Steinmetz (eds.),Eyeblink Classical Conditioning: Animal. Kluwer Academic Publishers.

  • Borgnis, R. L. (1993). Latent inhibition of multiple unit activity and eeg in rabbit hippocampus. Unpublished master’s thesis. Miami University, Oxford, OH.

    Google Scholar 

  • Bonardi, C. & G. Hall. (1996). Learned irrelevance: No more than the sum of CS and US preexposure effects?Journal of Experimental Psychology: Animal Behavior Processes, 22: 183–191.

    Article  Google Scholar 

  • Brelsford, J. & J. Theios. (1965). Single session conditioning of the nictitating membrane in the rabbit: Effect of intertrial interval.Psychonomic Science, 2: 81–82.

    Google Scholar 

  • Buhusi, C. V., J. A. Gray & N. A. Schmajuk. (1998). Perplexing effects of hippocampal lesions on latent inhibition: A neural network approach.Behavioral Neuroscience, 112 (2): 316–351.

    Article  PubMed  Google Scholar 

  • Channell, S. & G. Hall. (1983). Contextual effects in latent inhibition with an appetitive conditioning procedure.Animal Learning and Behavior, 11: 67–74.

    Article  Google Scholar 

  • Chen, G. & J. E. Steinmetz. (1998). A general purpose computer system for behavioral conditioning and neural recording experiments.Behavioral Research Methods, Instruments & Computers, 30: 384–391.

    Article  Google Scholar 

  • Chen G. & J. E. Steinmetz. (2000). Intra-cerebellar infusion of NMDA receptor antagonist AP5 disrupts classical eyeblink conditioning in rabbits.Brain Research, 887, 144–156.

    Article  PubMed  Google Scholar 

  • Clark, R. E. & L. R. Squire. (1999). Human eyeblink classical conditioning: Effects of manipulating awareness of the stimulus contingencies.Psychological Science, 10 (1): 14–18.

    Article  Google Scholar 

  • Clarke, M. E. & R. B. Hupka. (1974). The effects of stimulus duration and frequency of daily preconditioning stimulus exposures on latent inhibition in pavlovian conditioning of the rabbit nictitating membrane response.Bulletin of the Psychonomic Society, 4: 2225–2228.

    Google Scholar 

  • Durkin, M., L. Prescott, C. Joney, E. Frank, M. Niggel & D. Powel. (1990). Photoresistive measurement of the Pavlovian conditioned eyelid response in human subjects.Psychophysiology, 27: 599–603.

    Article  PubMed  Google Scholar 

  • Folstein, M., S. Folstein & P. McHugh. (1975). “Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician.Journal of Psychiatric Research, 12: 189–198.

    Article  PubMed  Google Scholar 

  • Frey, P. W., R. Masiak & G. Dugue. (1976). Unconditioned stimulus characteristics in rabbit eyelid conditioning.Journal of Experimental Psychology: Animal Behavior Processes, 2: 175–190.

    Article  PubMed  Google Scholar 

  • Gabrieli, J. D. E., R. McGlinchey-Berroth, M. C. Carrillo, M. A. Gluck, L. S. Cermak & J. F. Disterhoft. (1995). Intact delay-eyeblink classical conditioning in amnesia.Behavioral Neuroscience, 109 (5): 819–827.

    Article  PubMed  Google Scholar 

  • Gluck, M. & C. Myers. (1993). Hippocampal mediation of stimulus representation: A computational theory.Hippocampus, 3: 491–516.

    Article  PubMed  Google Scholar 

  • Gormezano, I., E. J. Kehoe & B. S. Marshall. (1983). Twenty years of classical conditioning research with the rabbit.Progress in Psychobiology and Physiological Psychology, 10: 197–275.

    Google Scholar 

  • Gormezano, I., N. Schneiderman, E. G. Deaux & I. Fuentes. (1962). Nictitating membrane: Classical conditioning and extinction in the albino rabbit.Science, 138: 33–34.

    Article  PubMed  Google Scholar 

  • Grant, D., H. Hake & D. Schneider. (1948). Effects of pretesting with the conditioned stimulus upon extinction of the conditioned eyelid response to light.American Journal of Psychology, 64: 247–251.

    Article  Google Scholar 

  • Grant, D., H. Hake, A. Riopelle & A. Kostlan. (1951). Effects of repeated pre-testing with conditioned stimulus upon extinction of the conditioned eyelid response to light.American Journal of Psychology, 64: 247–251.

    Article  PubMed  Google Scholar 

  • Hall, G. & S. Channell. (1985). Differential effects of contextual change on latent inhibition and on the habituation of an orienting response.Journal of Experimental Psychology: Animal Behavior Processes, 11: 470–481.

    Article  Google Scholar 

  • Hall, G. (1991).Perceptual and Associative Learning. Oxford: Clarendon Press.

    Book  Google Scholar 

  • Harvey, J., L. Gormezano & V. Cool-Hauser. (1983). Effects of scopolamine and methylscopolamine on classical conditioning of the rabbit nictitating membrane response.Journal of Pharmacology and Experimental Therapeutics, 225: 42–49.

    PubMed  Google Scholar 

  • Hernandez, L. L., S. L. Buchanan & D. A. Powell. (1981). CS pre-exposure: Latent inhibition and pavlovian conditioning of heart rate and eyeblink responses as a function of sex and CS intensity in rabbits.Animal Learning and Behavior, 9 (4): 513–518.

    Article  Google Scholar 

  • Jones, S. H., D. Hemsley, S. Ball & A. Serra. (1997). Disruption of the kamin blocking effect in schizophrenia and in normal subjects following amphetamine.Behavioural Brain Research, 88: 103–114.

    Article  PubMed  Google Scholar 

  • Katz, D. B., D. M. Shock & J. E. Steinmetz. (1995). Latent inhibition of the rabbit conditioned eyeblink is not reflected in hippocampal activity.Society for Neuroscience Abstracts, 21: 1218.

    Google Scholar 

  • Kim, J. J., D. J. Krupa & R. F. Thompson. (1998). Inhibitory cerebello-olivary projections and blocking effect in classical conditioning.Science, 279: 570–573.

    Article  PubMed  Google Scholar 

  • Lavond, D. & J. Steinmetz. (1989). An interface for the IBM-XT/AT and compatibles.Behavior Research Methods, Instruments and Computers, 21: 435–440.

    Article  Google Scholar 

  • Lubow, R. (1973). Latent Inhibition.Psychological Bulletin, 79: 398–407.

    Article  PubMed  Google Scholar 

  • — (1989).Latent Inhibition and Conditioned Attention Theory. Cambridge, England: Cambridge University Press.

    Book  Google Scholar 

  • Mackintosh, N. (1973). Stimulus selection: Learning to ignore stimuli that predict no change in reinforcement. In R. Hinde and J. Stevenson-Hinde (eds.),Constraints on Learning; Limitations and Predispositions (pp. 75–96). New York: Academic Press.

    Google Scholar 

  • Martin, I. & A. B. Levey. (1991). Blocking observed in human eyelid conditioning.Quarterly Journal of Experimental Psychology, 43B (3): 233–256.

    Google Scholar 

  • Matzel, L., T. Schachtman & R. Miller. (1988). Learned irrelevance exceeds the sum of CS-preexposure and US-preexposure deficits.Journal of Experimental Psychology: Animal Behavior Processes, 14: 311–319.

    Article  Google Scholar 

  • Miller, D. P. (1994). Hippocampal information processing and interactions with brain areas involved in inhibition of tone-signaled conditioned responses: An experimental and theoretical approach. Unpublished doctoral dissertation, Indiana University, Bloomington.

    Google Scholar 

  • Myers, C., B. Ermita, L. Oliver & M. Gluck. (1996). Learned irrelevance and the US exposure effect in human associative learning.Proceedings of the American Psychological Society Annual Meeting. San Francisco, CA.

  • Myers, C., B. McGlinchey-Berroth, S. Warren, L. Monti, C. Brawn & M. Gluck. (2000). Latent learning in medial temporal amnesia: Evidence for disrupted representational but preserved attentional processes.Neuropsychology, 14: 1–13.

    Article  Google Scholar 

  • Myers, C., L. Oliver, S. Warren & M. Gluck. (2000). Stimulus exposure effects in human associative learning.Quarterly Journal of Experimental Psychology B: Comparative and Physiological Psychology, 538: 173–187.

    Google Scholar 

  • Oades, R. D. & B. Muller. (1997). The development of conditioned blocking and monamine metabolism in children with attention-deficit-hyperactivity disorder or complex tics and healthy controls: An exploratory analysis.Behavioural Brain Research, 88:95–102.

    Article  PubMed  Google Scholar 

  • Overmier, J. & R. Wielkiewicz. (1983). On unpredictability as a causal factor in “Learned Helplessness.”Learning and Motivation, 14:324–337.

    Article  Google Scholar 

  • Perlmutter, L.. (1966). Effects of CS manipulations on the conditioned eyelid response: Compounding, generalization, the inter-CS interval, and preexposure.Psychonomic Monographic Supplements, 1:271–286.

    Google Scholar 

  • Plotkin, H. C. & D. A. Oakley. (1975). Backward conditioning in the rabbit (orytolagus cuniculus).Journal of Comparative and Physiological Psychology, 88:586–590.

    Article  PubMed  Google Scholar 

  • Prokasy, W. R., C. W. Spurr & N. A. Goodell. (1978). Pre-exposure to explicitly unpaired conditoned and unconditioned stimuli retards conditioned response emergence.Bulletin of the Psychonomic Society, 12: 155–158.

    Google Scholar 

  • Reiss, S. & A. R. Wagner. (1972). CS habituation produces a “latent inhibition effect” bun no active “conditioned inhibition.”Learning & Motivation, 3:237–245.

    Article  Google Scholar 

  • Robinson, G. B., R. L. Port & E. J. Stillwell. (1993). Latent inhibition of the classically conditioned rabbit nictitating membrane response is unaffected by nmda antagonist mk801.Psychobiology, 21(2):120–124.

    Google Scholar 

  • Rogers, R. F., D. B. Katz, R. E. Gorin & J. E. Steinmetz. (2001). Contextual contributions to the expression of latent inhibition.Society for Neuroscience Abstracts.

  • Romano, A. G.. (1999). Variations in cs associability and multiple unit hippocampal activity in the rabbit.Behavioural Brain Research, 103:163–173.

    Article  PubMed  Google Scholar 

  • Rush, A. N., B. L. Robinette & M. E. Stanton. (2001). Ontogenetic differences in the effects of unpaired stimulu preexposure on eyeblink conditioning in the rat.Developmental Psychobiology, 8–18.

  • Salafia, W. R. & A. M. Allan. (1980). Attentuation of latent inhibition by electrical stimulation of hippocampus.Physiology & Behavior, 24:1047–1051.

    Article  Google Scholar 

  • Salafia, W., F. Mis, W. Terry, R. Bartosiak & A. Daston. (1973). Conditioning of the nictitating membrane response of the rabbit (Oryctolagus cuniculus) as a function of length and degree of variation of intertrial interval.Animal Learning and Behavior, 1:109–115.

    Article  Google Scholar 

  • Scavio, M. J., R. T. Ross & L. M. McLeod. (1983). Perserveration of associative strength in rabbit nictitating membrane response conditioning.Animal Learning & Behavior, 11:91–94.

    Article  Google Scholar 

  • Schmajuk, N. A., J. A. Gray & Y. W. Lam. (1996). Latent inhibition: A neural network approach.Journal of Experimental Psychology: Animal Behavior Processes, 22:321–349.

    Article  PubMed  Google Scholar 

  • Schmajuk, N., Y. W. Lam & B. Christiansen. (1994). Latent inhibition of the rat eyeblink response: Effect of hippocampal aspiration lesions.Physiology and Behavior, 55 (3):597–601.

    Article  PubMed  Google Scholar 

  • Schmajuk, N. A. & J. W. Moore. (1988). The hippocampus and the classically conditioned nictitating membrane response: A real time attentional-associative model.Psychobiology, 16:20–35.

    Google Scholar 

  • Schnur, P. & C. J. Ksir. (1969). Latent inhibition in human eyelid conditioning.Journal of Experimental Psychology, 80 (2):388–389.

    Article  PubMed  Google Scholar 

  • Schnur, P. & R. E. Lubow. (1976). Latent inhibition: The effects of iti and cs intensity during pre-exposure.Learning & Motivation, 7:540–550.

    Article  Google Scholar 

  • Shohamy, D., M. Allen & M. Gluck. (2000). Dissociating entorhinal and hippocampal involvement in latent inhibition.Behavioral Neuroscience, 114:867–874.

    Article  PubMed  Google Scholar 

  • Siegel, S. (1969a). Effects of cs habituation on eyelid conditioning.Journal of Comparative and Physiological Psychology, 68 (2):245–248.

    Article  PubMed  Google Scholar 

  • — (1969b). Generalization of latent inhibition.Journal of Comparative and Physiological Psychology, 69 (1):157–159.

    Article  Google Scholar 

  • — (1970). Retention of latent inhibition.Psychonomic Society, 20:161–162.

    Google Scholar 

  • — & M. Domjan. (1971). Backward conditioning as an inhibitory procedure.Learning & Motivation, 2:1–11.

    Article  Google Scholar 

  • Solomon, P. R., G. Bennan & J. W. Moore. (1974). Latent inhibition of the rabbit’s nictitating membrane response as a function of cs intensity.Bulletin of the Psychonomic Society, 4:445–448.

    Google Scholar 

  • — & K. E. Gottfried. (1981). The septohippocampal cholinergic system and classical conditioning of the rabbit’s nictitating membrane response.Journal of Comparative and Physiological Psychology, 95:322–330.

    Article  PubMed  Google Scholar 

  • —, M. Groccia-Ellison, D. Flynn, J. Mirak, K. R. Edwards, A. Dunehew & M. E. Stanton. (1993). Disruption of human eyeblink conditioning after central cholinergic blockade with scopolamine.Behavioral Neuroscience, 107:271–279.

    Article  PubMed  Google Scholar 

  • —, A. C. Lohr & J. W. Moore. (1974). Latent inhibition of the rabbit’s nictitating membrane response: Summation tests for active inhibition as a function of the number of cs pre-exposure.Bulletin of the Psychonomic Society, 4:557–559.

    Google Scholar 

  • Solomon, P. & J. Moore. (1975). Latent inhibition and stimulus generalization of the classically conditioned nictitating membrane response in rabbits (Oryctolagus cuniculus) following dorsal hippocampal ablation.Journal of Comparative and Physiological Psychology, 89:1192–1203.

    Article  PubMed  Google Scholar 

  • —, D. Pomerleau, L. Bennett, J. James & D. Morse. (1989). Acquisition of the classically conditioned eyeblink response in humans over the life span.Psychology and Aging, 4:34–41.

    Article  PubMed  Google Scholar 

  • Steinmetz, J. E.. (1999). A renewed interest in human classical eyeblink conditioning.Psychological Science, 10:24–25.

    Article  Google Scholar 

  • Suboski, M. D., V. DiLollo & I. Gormezano. (1964). Effects of unpaired pre-acquisition exposure of CS and UCS on classical conditioning of the nictitating membrane response of the albino rabbit.Psychological Reports, 15:571–576.

    Google Scholar 

  • Thompson, L. T., J. R. Moyer, E. Akase & J. F. Disterhoft. (1994). A system for quantitative analysis of associative learning, Part 1. Hardware interfaces with cross-species applications.Journal of neuroscience Methods, 54:109–117.

    Article  PubMed  Google Scholar 

  • Thompson, R. F., S. Bao, L. Chen, B. D. Cipriano, J. S. Grethe, J. J. Kim, J. K. Thompson, J. A. Tracy, M. S. Weninger & D. J. Krupa. (1997). Associative learning. In B. J. Bradley, R. A. Harris, P. Jenner (Series eds.) and J. D. Schmahmann (Vol. ed.),International Review of Neurobiology: The Cerebellum and Cognition. San Diego: Academic Press.

    Google Scholar 

  • Tracy, J., S. S. Ghose, T. Stetcher, R. M. McFall & J. E. Steinmetz. (1999). Classical conditioning in a nonclinical obsessive-compulsive population.Psychological Science, 10(1):9–13.

    Article  Google Scholar 

  • Weiner, I. & J. Feldon, J.. (1997). The switching model of latent inhibition: An update of neural substrates.Behavioural Brain Research, 88:11–25.

    Article  PubMed  Google Scholar 

  • Woodruff-Pak D. S. & I. S. Santos. (2000). Nicotinic modulation in an animal model of a form of associative learning impaired in alzheimer’s disease.Behaviour Brain Research, 113:11–19.

    Article  Google Scholar 

  • Woodruff-Pak, D. S. & J. E. Steinmetz, Eds. (2000a).Eyeblink Classical Conditioning Vol. 1: Human Applications, Boston: Kluwer.

    Google Scholar 

  • Woodruff-Pak, D. S. & J. E. Steinmetz, Eds. (2000b).Eyeblink Classical Conditioning, Vol. 2: Animal Models. Boston: Kluwer.

    Google Scholar 

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Authors and Affiliations

  1. Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ

    Mark A. Gluck & Geoffrey Schnirman

  2. Department of Psychology, Rutgers University, Newark, NJ

    Catherine E. Myers

  3. Department of Psychology, Fordham University, New York, NY

    Geoffrey Schnirman

  4. Dept. of Psychology, College of Charleston, 29424, Charleston, SC

    M. Todd Allen Ph.D.

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  1. M. Todd Allen Ph.D.
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  2. Lori Chelius
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  3. Vivek Masand
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  4. Mark A. Gluck
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  5. Catherine E. Myers
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  6. Geoffrey Schnirman
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Correspondence to M. Todd Allen Ph.D..

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Allen, M.T., Chelius, L., Masand, V. et al. A comparison of latent inhibition and learned irrelevance pre-exposure effects in rabbit and human eyeblink conditioning. Integrative Physiological & Behavioral Science 37, 188–214 (2002). https://doi.org/10.1007/BF02734181

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